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    Dancr differentiation antagonizing non-protein coding RNA [ Mus musculus (house mouse) ]

    Gene ID: 70036, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dancrprovided by MGI
    Official Full Name
    differentiation antagonizing non-protein coding RNAprovided by MGI
    Primary source
    MGI:MGI:1917286
    See related
    Ensembl:ENSMUSG00000106943 AllianceGenome:MGI:1917286
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700023E23Rik
    Summary
    Acts upstream of or within response to wounding. Is expressed in limb skin; lung; lung epithelium; and lung mesenchyme. Orthologous to human DANCR (differentiation antagonizing non-protein coding RNA). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 14.0), CNS E14 (RPKM 13.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dancr in Genome Data Viewer
    Location:
    5 C3.3; 5 39.38 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (74253780..74254998)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (74093060..74094337)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 46 Neighboring gene ubiquitin specific peptidase 46, opposite strand 1 Neighboring gene predicted gene, 52817 Neighboring gene STARR-positive B cell enhancer ABC_E8062 Neighboring gene small nucleolar RNA, H/ACA box 26 Neighboring gene predicted gene, 32002 Neighboring gene RAS-like, family 11, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DANCR deletion retards the initiation and progression of hepatocellular carcinoma based on gene knockout and patient-derived xenograft in situ hepatoma mice model. Gan X, et al. Cancer Lett, 2022 Dec 1. PMID 36183859
    2. Exosomes Secreted by Mesenchymal Stem Cells Induce Immune Tolerance to Mouse Kidney Transplantation via Transporting LncRNA DANCR. Wu X, et al. Inflammation, 2022 Feb. PMID 34596768
    3. Effects of lncRNA DANCR on proliferation and differentiation of osteoblasts by regulating the Wnt/β-catenin pathway. Jiang SY, et al. Eur Rev Med Pharmacol Sci, 2019 Jul. PMID 31298307
    4. DANCR promotes glioma cell autophagy and proliferation via the miR‑33b/DLX6/ATG7 axis. Yu W, et al. Oncol Rep, 2023 Feb. PMID 36601767, Free PMC Article
    5. Long non-coding RNA DANCR regulate MLL3 and thereby it determines the progression of pancreatic cancer. Liu Y, et al. J BUON, 2020 Jul-Aug. PMID 33099938

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dancr-BRG1 regulates Nfatc1 transcription and Pgc1beta-dependent metabolic shifts in osteoclastogenesis.
      Title: Dancr-BRG1 regulates Nfatc1 transcription and Pgc1β-dependent metabolic shifts in osteoclastogenesis.
    2. DANCR promotes glioma cell autophagy and proliferation via the miR33b/DLX6/ATG7 axis.
      Title: DANCR promotes glioma cell autophagy and proliferation via the miR‑33b/DLX6/ATG7 axis.
    3. Exosomes Secreted by Mesenchymal Stem Cells Induce Immune Tolerance to Mouse Kidney Transplantation via Transporting LncRNA DANCR.
      Title: Exosomes Secreted by Mesenchymal Stem Cells Induce Immune Tolerance to Mouse Kidney Transplantation via Transporting LncRNA DANCR.
    4. Inhibition of the lncRNA DANCR attenuates cardiomyocyte injury induced by oxygen-glucose deprivation via the miR-19a-3p/MAPK1 axis.
      Title: Inhibition of the lncRNA DANCR attenuates cardiomyocyte injury induced by oxygen-glucose deprivation via the miR-19a-3p/MAPK1 axis.
    5. Long non-coding RNA DANCR regulate MLL3 and thereby it determines the progression of pancreatic cancer.
      Title: Long non-coding RNA DANCR regulate MLL3 and thereby it determines the progression of pancreatic cancer.
    6. Effects of lncRNA DANCR on proliferation and differentiation of osteoblasts by regulating the Wnt/beta-catenin pathway.
      Title: Effects of lncRNA DANCR on proliferation and differentiation of osteoblasts by regulating the Wnt/β-catenin pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Other Names

    • hypothetical gene supported by AK045300

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_015531.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC115823
      Related
      ENSMUST00000117249.3

    2. NR_145131.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC115823
      Related
      ENSMUST00000120364.3

    3. NR_145133.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC115823

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      74253780..74254998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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