Ppm1l protein phosphatase, Mg2+/Mn2+ dependent, 1L [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppm1lprovided by RGD
Official Full Name: protein phosphatase, Mg2+/Mn2+ dependent, 1Lprovided by RGD
Primary source: RGD:1305220
See related: Ensembl:ENSRNOG00000067239 AllianceGenome:RGD:1305220
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to act upstream of or within MAPK cascade and transmembrane receptor protein serine/threonine kinase signaling pathway. Orthologous to human PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 125.5), Uterus (RPKM 105.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (155876605..156149371)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (153566653..153839434)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (165932240..166218774)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CERT is a physiological substrate of PP2Cepsilon and that dephosphorylation of CERT by PP2Cepsilon may play an important role in the regulation of ceramide trafficking from the ER to the Golgi apparatus.
Title: Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes.

Submit: New GeneRIF Correction

General gene information

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Markers

D2Got112 (e-PCR)
- UniSTS:114698

RH142056 (e-PCR)
- UniSTS:224046

BE107865 (e-PCR)
- UniSTS:247095

BF397820 (e-PCR)
- UniSTS:246331

AU029101 (e-PCR)
- UniSTS:111697

RH132200 (e-PCR)
- UniSTS:215483

RH135323 (e-PCR)
- UniSTS:218600

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein phosphatase 1L

NP_001101151.1

EC 3.1.3.16

XP_017446354.1

EC 3.1.3.16

XP_038958215.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107681.4 → NP_001101151.1 protein phosphatase 1L

See identical proteins and their annotated locations for NP_001101151.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I5ZU99, A6J5N2

Related

ENSRNOP00000082838.1, ENSRNOT00000095588.1

Conserved Domains (1) summary

cd00143
Location:93 → 351

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

155876605..156149371

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102287.2 → XP_038958215.1 protein phosphatase 1L isoform X2

Conserved Domains (1) summary

cd00143
Location:12 → 172

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_017590865.3 → XP_017446354.1 protein phosphatase 1L isoform X1

UniProtKB/TrEMBL

A0A8I6A4H5

Related

ENSRNOP00000085836.1