Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hnrnpa2b1provided by RGD
Official Full Name: heterogeneous nuclear ribonucleoprotein A2/B1provided by RGD
Primary source: RGD:1310403
See related: Ensembl:ENSRNOG00000011175 AllianceGenome:RGD:1310403
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: hnRNP; Hnrpa2; Hnrpa2b1
Summary: Enables DNA polymerase binding activity and nucleic acid binding activity. Involved in several processes, including chromosome organization; mRNA export from nucleus; and regulation of DNA metabolic process. Located in several cellular components, including chromosome; neuronal ribonucleoprotein granule; and nuclear lumen. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study rheumatoid arthritis. Biomarker of hepatocellular carcinoma; pancreatic carcinoma; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in inclusion body myopathy with Paget disease of bone and frontotemporal dementia and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2. Orthologous to human HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 1081.1), Spleen (RPKM 825.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (81867354..81875886, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (80534659..80545297, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (81237496..81241281, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

lnc-HC negatively regulates cholesterol metabolism within hepatocytes through physical interaction with hnRNPA2B1. By further binding to the target messenger RNA of Cyp7a1 or Abca1, the lnc-HC-hnRNPA2B1 complex decreases expressions of the two genes that are implicated in cellular cholesterol excretion.
Title: A novel long noncoding RNA Lnc-HC binds hnRNPA2B1 to regulate expressions of Cyp7a1 and Abca1 in hepatocytic cholesterol metabolism.
These results show that the distribution of hnRNP A2/B1 is regulated by BDNF.
Title: Neuronal activity induces synaptic delivery of hnRNP A2/B1 by a BDNF-dependent mechanism in cultured hippocampal neurons.
data suggest that a prominent down-regulation of hnRNP-A2/B1 during hypoxia is associated with the post-transcriptional suppression of hASH1 synthesis.
Title: Shutdown of achaete-scute homolog-1 expression by heterogeneous nuclear ribonucleoprotein (hnRNP)-A2/B1 in hypoxia.
We describe a molecular mechanism in which inducible interactions of noncanonical RNA motif structures with targeting factor heterogeneous nuclear ribonucleoprotein (hnRNP) A2 form the basis for activity-dependent dendritic RNA targeting.
Title: Interactions of noncanonical motifs with hnRNP A2 promote activity-dependent RNA transport in neurons.
hnRNP A2/B1 is involved in the tissue-specific regulation of ENaC biosynthesis and may coordinate the response of other genes relevant for transepithelial Na(+) reabsorption by aldosterone.
Title: Heterogeneous nuclear ribonucleoprotein A2/B1 is a tissue-specific aldosterone target gene with prominent induction in the rat distal colon.
Binding to hnRNP A2 and ensuing dendritic delivery are effectively competed by RNAs with CGG triplet repeat expansions
Title: Spatial code recognition in neuronal RNA targeting: role of RNA-hnRNP A2 interactions.
Akt1-mediated phosphorylation is crucial for the activation and recruitment of hnRNPA2 to the enhanceosome complex.
Title: Activation of Akt is essential for the propagation of mitochondrial respiratory stress signaling and activation of the transcriptional coactivator heterogeneous ribonucleoprotein A2.
Over-expression of hnRNP A2/B1 is associated with non-small cell lung cancer.
Title: Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues.
Increased expression and cytoplasmic localization of hnRNP A2/B1 is associated with the development of hepatocellular carcinoma.
Title: Up-regulation and subcellular localization of hnRNP A2/B1 in the development of hepatocellular carcinoma.
Results showed that expression of hnRNP A2/B1 was significantly downregulated in cerebral cortex and hippocampus from 3 to 24 hr of reperfusion after middle cerebral artery occlusion for 120 min, but significantly upregulated at 48 hr of reperfusion.
Title: Histochemical mapping of hnRNP A2/B1 in rat brain after ischemia-reperfusion insults.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA963720 (e-PCR)
- UniSTS:248107

AW528373 (e-PCR)
- UniSTS:246601

RH139245 (e-PCR)
- UniSTS:221331

D1S3697 (e-PCR)
- UniSTS:474275

MARC_1211-1212:991931105:1 (e-PCR)
- UniSTS:230853

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA polymerase binding	IPI Inferred from Physical Interaction more info	PubMed
enables G-rich strand telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables N6-methyladenosine-containing RNA reader activity	IEA Inferred from Electronic Annotation more info
enables N6-methyladenosine-containing RNA reader activity	ISO Inferred from Sequence Orthology more info
enables N6-methyladenosine-containing RNA reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA CDS binding	IDA Inferred from Direct Assay more info	PubMed
enables miRNA binding	IEA Inferred from Electronic Annotation more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular condensate scaffold activity	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables pre-mRNA intronic binding	IEA Inferred from Electronic Annotation more info
enables pre-mRNA intronic binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables regulatory region RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded telomeric DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded telomeric DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G-quadruplex DNA unwinding	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in RNA transport	ISO Inferred from Sequence Orthology more info
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mRNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in miRNA transport	IEA Inferred from Electronic Annotation more info
involved_in miRNA transport	ISO Inferred from Sequence Orthology more info
involved_in miRNA transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of telomere maintenance via telomere lengthening	IDA Inferred from Direct Assay more info	PubMed
involved_in primary miRNA processing	IEA Inferred from Electronic Annotation more info
involved_in primary miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in primary miRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to mineralocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in telomere capping	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Cajal body	IDA Inferred from Direct Assay more info	PubMed
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoproteins A2/B1

Names: heterogeneous nuclear ribonucleoprotein A2; heterogeneous nuclear ribonucleoprotein B0a; heterogeneous nuclear ribonucleoprotein B0b; heterogeneous nuclear ribonucleoprotein B1; hnRNP A2 / hnRNP B1; hnRNP A2/B1; nuclear ribonucleoprotein particle A2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001104613.2 → NP_001098083.2 heterogeneous nuclear ribonucleoproteins A2/B1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

A7VJC1, A7VJC2, A7VJC3, A7VJC4

UniProtKB/TrEMBL

F1LNF1

Related

ENSRNOP00000015152.4, ENSRNOT00000015152.7

Conserved Domains (3) summary

pfam11627
Location:302 → 326

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:112 → 191

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:19 → 99

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

81867354..81875886 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286268.1 → XP_063142338.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X4

UniProtKB/TrEMBL

A0A8I5YC50
XM_063286267.1 → XP_063142337.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X4

UniProtKB/TrEMBL

A0A8I5YC50
XM_039107793.2 → XP_038963721.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

UniProtKB/Swiss-Prot

A7VJC1, A7VJC2, A7VJC3, A7VJC4

UniProtKB/TrEMBL

A0A8I5Y7N4, A6K0N6

Related

ENSRNOP00000077328.1

Conserved Domains (3) summary

pfam11627
Location:290 → 314

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:100 → 179

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:7 → 87

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
XM_063286263.1 → XP_063142333.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

UniProtKB/Swiss-Prot

A7VJC1, A7VJC2, A7VJC3, A7VJC4

UniProtKB/TrEMBL

A0A8I5Y7N4, A6K0N6
XM_063286264.1 → XP_063142334.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

UniProtKB/Swiss-Prot

A7VJC1, A7VJC2, A7VJC3, A7VJC4

UniProtKB/TrEMBL

A0A8I5Y7N4, A6K0N6
XM_039107795.2 → XP_038963723.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

UniProtKB/TrEMBL

A0A8I5YC50

Conserved Domains (3) summary

pfam11627
Location:260 → 286

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:112 → 191

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:19 → 99

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
XM_039107790.2 → XP_038963718.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

UniProtKB/Swiss-Prot

A7VJC1, A7VJC2, A7VJC3, A7VJC4

UniProtKB/TrEMBL

F1LNF1

Conserved Domains (3) summary

pfam11627
Location:302 → 326

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:112 → 191

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:19 → 99

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
XM_039107791.2 → XP_038963719.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

UniProtKB/Swiss-Prot

A7VJC1, A7VJC2, A7VJC3, A7VJC4

UniProtKB/TrEMBL

F1LNF1

Conserved Domains (3) summary

pfam11627
Location:302 → 326

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:112 → 191

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:19 → 99

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
XM_063286265.1 → XP_063142335.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

UniProtKB/TrEMBL

A0A8I5YC50
XM_039107789.2 → XP_038963717.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1

UniProtKB/Swiss-Prot

A7VJC1, A7VJC2, A7VJC3, A7VJC4

UniProtKB/TrEMBL

F1LNF1

Conserved Domains (3) summary

pfam11627
Location:302 → 326

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:112 → 191

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:19 → 99

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
XM_039107796.2 → XP_038963724.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X4

UniProtKB/TrEMBL

A0A8I5YC50

Conserved Domains (3) summary

pfam11627
Location:248 → 274

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:100 → 179

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:7 → 87

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
XM_039107792.2 → XP_038963720.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X2

UniProtKB/Swiss-Prot

A7VJC1, A7VJC2, A7VJC3, A7VJC4

UniProtKB/TrEMBL

A0A8I5Y7N4, A6K0N6

Related

ENSRNOP00000015325.6

Conserved Domains (3) summary

pfam11627
Location:290 → 314

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:100 → 179

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:7 → 87

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins
XM_039107794.2 → XP_038963722.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform X3

UniProtKB/TrEMBL

A0A8I5YC50

Conserved Domains (3) summary

pfam11627
Location:260 → 286

HnRNPA1; Nuclear factor hnRNPA1

cd12581
Location:112 → 191

RRM2_hnRNPA2B1; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins

cd12762
Location:19 → 99

RRM1_hnRNPA2B1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) and similar proteins