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    Arhgap42 Rho GTPase activating protein 42 [ Mus musculus (house mouse) ]

    Gene ID: 71544, updated on 8-May-2024

    Summary

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    Official Symbol
    Arhgap42provided by MGI
    Official Full Name
    Rho GTPase activating protein 42provided by MGI
    Primary source
    MGI:MGI:1918794
    See related
    Ensembl:ENSMUSG00000050730 AllianceGenome:MGI:1918794
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030420J04Rik
    Summary
    Enables GTPase activator activity. Acts upstream of or within negative regulation of Rho protein signal transduction; negative regulation of systemic arterial blood pressure; and negative regulation of vascular associated smooth muscle contraction. Orthologous to human ARHGAP42 (Rho GTPase activating protein 42). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.1), limb E14.5 (RPKM 6.3) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgap42 in Genome Data Viewer
    Location:
    9 A1; 9 2.46 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (8992508..9239032, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (8992507..9239027, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 6 Neighboring gene STARR-seq mESC enhancer starr_23249 Neighboring gene predicted gene, 32014 Neighboring gene STARR-seq mESC enhancer starr_23250 Neighboring gene STARR-seq mESC enhancer starr_23251 Neighboring gene STARR-seq mESC enhancer starr_23252 Neighboring gene STARR-seq mESC enhancer starr_23253 Neighboring gene STARR-seq mESC enhancer starr_23254 Neighboring gene STARR-seq mESC enhancer starr_23255 Neighboring gene progesterone receptor Neighboring gene STARR-seq mESC enhancer starr_23256 Neighboring gene STARR-seq mESC enhancer starr_23257 Neighboring gene STARR-seq mESC enhancer starr_23258 Neighboring gene STARR-seq mESC enhancer starr_23259 Neighboring gene predicted gene, 16833 Neighboring gene predicted gene, 51662 Neighboring gene predicted gene, 22815

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular Regulation of the RhoGAP GRAF3 and Its Capacity to Limit Blood Pressure In Vivo. Dee RA, et al. Cells, 2020 Apr 22. PMID 32331391, Free PMC Article
    2. ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility. Luo W, et al. J Cell Sci, 2017 Jul 15. PMID 28584191, Free PMC Article
    3. Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding. Bai X, et al. J Clin Invest, 2017 Feb 1. PMID 28112683, Free PMC Article
    4. The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension. Bai X, et al. Nat Commun, 2013. PMID 24335996, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular Regulation of the RhoGAP GRAF3 and Its Capacity to Limit Blood Pressure In Vivo.
      Title: Molecular Regulation of the RhoGAP GRAF3 and Its Capacity to Limit Blood Pressure In Vivo.
    2. Phosphorylation of ARHGAP42 Tyr-376 is revealed as a novel regulatory event by which Src can affect actin dynamics through RhoA inhibition.
      Title: ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility.
    3. Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding
      Title: Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding.
    4. GRAF3 is expressed in a smooth muscle-restricted fashion.
      Title: The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of systemic arterial blood pressure IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 42
    Names
    VRho GTPase activating protein 42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372563.1 → NP_001359492.1  rho GTPase-activating protein 42 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC113589, AC160964, AC162803
      Conserved Domains (4) summary
      cd07634
      Location:19 → 225
      BAR_GAP10-like; The Bin/Amphiphysin/Rvs (BAR) domain of Rho GTPase activating protein 10-like
      cd12066
      Location:821 → 875
      SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
      cd01249
      Location:267 → 376
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:369 → 567
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    2. NM_001372564.1 → NP_001359493.1  rho GTPase-activating protein 42 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113589, AC160964, AC162803
      Conserved Domains (4) summary
      cd07634
      Location:19 → 225
      BAR_GAP10-like; The Bin/Amphiphysin/Rvs (BAR) domain of Rho GTPase activating protein 10-like
      cd12066
      Location:800 → 854
      SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
      cd01249
      Location:267 → 376
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:369 → 567
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    3. NM_001372565.1 → NP_001359494.1  rho GTPase-activating protein 42 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC113589, AC160964, AC162803
      Conserved Domains (3) summary
      cd01249
      Location:267 → 376
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:369 → 515
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. NM_001372566.1 → NP_001359495.1  rho GTPase-activating protein 42 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113589, AC160964, AC162803
      Conserved Domains (3) summary
      cd01249
      Location:233 → 342
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:335 → 481
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:19 → 191
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. NM_001372567.1 → NP_001359496.1  rho GTPase-activating protein 42 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC113589, AC160964, AC162803
      Conserved Domains (2) summary
      cd01249
      Location:267 → 375
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. NM_001372568.1 → NP_001359497.1  rho GTPase-activating protein 42 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC113589, AC160964, AC162803
      Conserved Domains (1) summary
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    7. NM_001372569.1 → NP_001359498.1  rho GTPase-activating protein 42 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC113589, AC160964, AC162803
      Conserved Domains (1) summary
      cl12013
      Location:19 → 201
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    8. NM_001372570.1 → NP_001359499.1  rho GTPase-activating protein 42 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC113589, AC160964, AC162803
      Conserved Domains (1) summary
      cl12013
      Location:19 → 193
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    9. NM_027823.2 → NP_082099.1  rho GTPase-activating protein 42 isoform 3

      See identical proteins and their annotated locations for NP_082099.1

      Status: VALIDATED

      Source sequence(s)
      AC113589, AC160964, AC162803
      Consensus CDS
      CCDS52720.1
      UniProtKB/Swiss-Prot
      B2RQE8
      Related
      ENSMUSP00000091419.5, ENSMUST00000093893.12
      Conserved Domains (4) summary
      cd12066
      Location:787 → 841
      SH3_GRAF3; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 3
      cd01249
      Location:233 → 342
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:335 → 533
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:19 → 191
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      8992508..9239032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RQE8.1 GenPept UniProtKB/Swiss-Prot:B2RQE8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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