Riok3 RIO kinase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Riok3provided by MGI
Official Full Name: RIO kinase 3provided by MGI
Primary source: MGI:MGI:1914128
See related: Ensembl:ENSMUSG00000024404 AllianceGenome:MGI:1914128
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sudd; D18Ertd331e; 1200013N13Rik; E130306C24Rik
Summary: Predicted to enable caspase binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to organic cyclic compound; negative regulation of intracellular signal transduction; and positive regulation of interferon-beta production. Predicted to act upstream of or within defense response to other organism; phosphorylation; and ribosome biogenesis. Predicted to be located in cytoplasm. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol. Is expressed in ganglia; sensory organ; trigeminal nerve; and vibrissa. Orthologous to human RIOK3 (RIO kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14 (RPKM 11.9), CNS E11.5 (RPKM 11.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 6.15 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (12259114..12290424)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (12126091..12157367)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RIOK3 potentially regulates osteogenesis-related pathways in ankylosing spondylitis and the differentiation of bone marrow mesenchymal stem cells.
Title: RIOK3 potentially regulates osteogenesis-related pathways in ankylosing spondylitis and the differentiation of bone marrow mesenchymal stem cells.
Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
Title: Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
down-regulation of miR-191 is essential for erythroid chromatin condensation and enucleation by allowing up-regulation of Riok3 and Mxi1
Title: miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI987788 (e-PCR)
- UniSTS:178496

RH126973 (e-PCR)
- UniSTS:167234

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Riok3 (e-PCR), detects polymorphism
- UniSTS:527518

MARC_21325-21326:1032965451:1 (e-PCR)
- UniSTS:268530

D18Mit229 (e-PCR), detects polymorphism
- UniSTS:128247

RH124706 (e-PCR)
- UniSTS:161528

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables caspase binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to dsDNA	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dsRNA	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in maturation of SSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of SSU-rRNA	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MDA-5 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of preribosome, small subunit precursor	IBA Inferred from Biological aspect of Ancestor more info
part_of preribosome, small subunit precursor	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase RIO3

Names: sudD, suppressor of bimD6 homolog

NP_077144.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024182.4 → NP_077144.2 serine/threonine-protein kinase RIO3

See identical proteins and their annotated locations for NP_077144.2

Status: PROVISIONAL

Source sequence(s)

AK147074

Consensus CDS

CCDS29062.1

UniProtKB/Swiss-Prot

Q3UI51, Q8CIC1, Q9DBU3

UniProtKB/TrEMBL

Q3TJT2, Q3UYW1, Q3V2R6

Related

ENSMUSP00000025270.7, ENSMUST00000025270.8

Conserved Domains (2) summary

COG1718
Location:214 → 461

RIO1; Serine/threonine-protein kinase RIO1 [Signal transduction mechanisms]

cd05146
Location:253 → 453

RIO3_euk; Catalytic domain of the atypical protein serine kinase, RIO3 kinase