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    Pm20d2 peptidase M20 domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 242377, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pm20d2provided by MGI
    Official Full Name
    peptidase M20 domain containing 2provided by MGI
    Primary source
    MGI:MGI:2685270
    See related
    Ensembl:ENSMUSG00000054659 AllianceGenome:MGI:2685270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm424; Acy1l2
    Summary
    Enables dipeptidase activity. Acts upstream of or within proteolysis and regulation of cellular protein metabolic process. Predicted to be located in nucleoplasm. Orthologous to human PM20D2 (peptidase M20 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart adult (RPKM 11.4), adrenal adult (RPKM 9.5) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pm20d2 in Genome Data Viewer
    Location:
    4 A5; 4 14.71 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (33170309..33189732, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (33170401..33189737, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit rho 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:33159852-33160053 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho 1 Neighboring gene STARR-seq mESC enhancer starr_09882 Neighboring gene predicted gene 11930 Neighboring gene serine and arginine-rich splicing factor 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase. Veiga-da-Cunha M, et al. J Biol Chem, 2014 Jul 11. PMID 24891507, Free PMC Article
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PM20D2 hydrolyzed beta-alanyl-lysine, beta-alanyl-ornithine, gamma-aminobutyryl-lysine, and gamma-aminobutyryl-ornithine as its best substrates.
      Title: Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables para-aminobenzoyl-glutamate hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in folic acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    xaa-Arg dipeptidase
    Names
    aminoacylase 1-like 2
    aminoacylase-1-like protein 2
    peptidase M20 domain-containing protein 2
    NP_001030039.2
    NP_001406369.1
    NP_001406370.1
    NP_001406371.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034867.3 → NP_001030039.2  xaa-Arg dipeptidase isoform 2

      See identical proteins and their annotated locations for NP_001030039.2

      Status: VALIDATED

      Source sequence(s)
      AL670464
      Consensus CDS
      CCDS51136.1
      UniProtKB/Swiss-Prot
      A3KG59, Q3ULU7
      Related
      ENSMUSP00000095783.3, ENSMUST00000098181.9
      Conserved Domains (2) summary
      cd05672
      Location:30 → 401
      M20_ACY1L2_like; M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily
      COG1473
      Location:34 → 389
      AbgB; Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]

    2. NM_001419440.1 → NP_001406369.1  xaa-Arg dipeptidase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL670464

    3. NM_001419441.1 → NP_001406370.1  xaa-Arg dipeptidase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL670464
      Related
      ENSMUSP00000113669.2, ENSMUST00000119167.2

    4. NM_001419442.1 → NP_001406371.1  xaa-Arg dipeptidase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL670464

    RNA

    1. NR_185084.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL670464

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      33170309..33189732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004941890.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A3KG59.1 GenPept UniProtKB/Swiss-Prot:A3KG59

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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