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    Acox2 acyl-Coenzyme A oxidase 2, branched chain [ Mus musculus (house mouse) ]

    Gene ID: 93732, updated on 8-May-2024

    Summary

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    Official Symbol
    Acox2provided by MGI
    Official Full Name
    acyl-Coenzyme A oxidase 2, branched chainprovided by MGI
    Primary source
    MGI:MGI:1934852
    See related
    Ensembl:ENSMUSG00000021751 AllianceGenome:MGI:1934852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    THCCox
    Summary
    Predicted to enable 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity; anion binding activity; and palmitoyl-CoA oxidase activity. Predicted to be involved in several processes, including fatty acid metabolic process; lipid homeostasis; and positive regulation of response to oxidative stress. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in peroxisome. Is expressed in several structures, including heart ventricle; liver; metanephros; and trunk. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 6. Orthologous to human ACOX2 (acyl-CoA oxidase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 75.3), kidney adult (RPKM 54.4) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acox2 in Genome Data Viewer
    Location:
    14 A1; 14 4.77 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (14210406..14244262)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (8225511..8259019, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2610318M16 gene Neighboring gene FAM3 metabolism regulating signaling molecule D Neighboring gene family with sequence similarity 107, member A Neighboring gene STARR-seq mESC enhancer starr_35868 Neighboring gene STARR-seq mESC enhancer starr_35867 Neighboring gene potassium channel tetramerisation domain containing 6 Neighboring gene predicted gene, 53823

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice. Zhang Y, et al. Cell Death Dis, 2022 Mar 29. PMID 35351852, Free PMC Article
    2. The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism. Yubero P, et al. Endocrinology, 2004 Sep. PMID 15178647
    3. Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse. Huyghe S, et al. Biochem J, 2001 Feb 1. PMID 11171065, Free PMC Article
    4. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647
    5. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-CoA oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-CoA oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal acyl-coenzyme A oxidase 2
    Names
    3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase
    3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase
    THCA-CoA oxidase
    branched chain acyl-CoA oxidase
    trihydroxycoprostanoyl-CoA oxidase
    NP_001155139.1
    NP_444345.2
    XP_006518171.1
    XP_036014833.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161667.1 → NP_001155139.1  peroxisomal acyl-coenzyme A oxidase 2

      See identical proteins and their annotated locations for NP_001155139.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CT025547
      Consensus CDS
      CCDS36801.1
      UniProtKB/Swiss-Prot
      Q8VCB0, Q9QXD1
      UniProtKB/TrEMBL
      Q3UNF3
      Related
      ENSMUSP00000022271.8, ENSMUST00000022271.14
      Conserved Domains (1) summary
      cd01150
      Location:20 → 655
      AXO; Peroxisomal acyl-CoA oxidase

    2. NM_053115.2 → NP_444345.2  peroxisomal acyl-coenzyme A oxidase 2

      See identical proteins and their annotated locations for NP_444345.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CT025547
      Consensus CDS
      CCDS36801.1
      UniProtKB/Swiss-Prot
      Q8VCB0, Q9QXD1
      UniProtKB/TrEMBL
      Q3UNF3
      Related
      ENSMUSP00000126464.2, ENSMUST00000164598.8
      Conserved Domains (1) summary
      cd01150
      Location:20 → 655
      AXO; Peroxisomal acyl-CoA oxidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      14210406..14244262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158940.1 → XP_036014833.1  peroxisomal acyl-coenzyme A oxidase 2 isoform X2

      UniProtKB/TrEMBL
      Q3UNF3
      Conserved Domains (1) summary
      cl09933
      Location:20 → 618
      ACAD; Acyl-CoA dehydrogenase

    2. XM_006518108.5 → XP_006518171.1  peroxisomal acyl-coenzyme A oxidase 2 isoform X1

      See identical proteins and their annotated locations for XP_006518171.1

      UniProtKB/Swiss-Prot
      Q8VCB0, Q9QXD1
      UniProtKB/TrEMBL
      Q3UNF3
      Conserved Domains (1) summary
      cd01150
      Location:20 → 655
      AXO; Peroxisomal acyl-CoA oxidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXD1.2 GenPept UniProtKB/Swiss-Prot:Q9QXD1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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