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    Gdap2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 59173, updated on 10-May-2024

    Summary

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    Official Symbol
    Gdap2provided by FlyBase
    Primary source
    FLYBASE:FBgn0042135
    Locus tag
    Dmel_CG18812
    See related
    AllianceGenome:FB:FBgn0042135
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12040; CG18812; CG18813; Dmel\CG18812
    Summary
    Involved in response to oxidative stress and response to starvation. Is expressed in adult head. Used to study autosomal recessive spinocerebellar ataxia 27. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 27. Orthologous to human GDAP2 (ganglioside induced differentiation associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Gdap2 in Genome Data Viewer
    Location:
    43E12-43E13; 2-57 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7716807..7735622, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3604312..3623127, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Diacylglycerol O-acyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45108 Neighboring gene cinnabar

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GDAP2 mutations implicate susceptibility to cellular stress in a new form of cerebellar ataxia. Eidhof I, et al. Brain, 2018 Sep 1. PMID 30084953, Free PMC Article
    2. Modulation of the activity of a polycomb-group response element in Drosophila by a mutation in the transcriptional activator woc. Noyes A, et al. G3 (Bethesda), 2011 Nov. PMID 22384357, Free PMC Article
    3. New Drosophila Long-Term Memory Genes Revealed by Assessing Computational Function Prediction Methods. Kacsoh BZ, et al. G3 (Bethesda), 2019 Jan 9. PMID 30463884, Free PMC Article
    4. Identification of Genes Contributing to a Long Circadian Period in Drosophila Melanogaster. Kumar S, et al. J Biol Rhythms, 2021 Jun. PMID 33274675, Free PMC Article
    5. Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. Gan Q, et al. Cell Res, 2010 Jul. PMID 20440302, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Gdap2
    Names
    CG18812-PA
    CG18812-PB
    CG18812-PC
    CG18812-PD
    CG18812-PE
    CG18812-PF
    Gdap2-PA
    Gdap2-PB
    Gdap2-PC
    Gdap2-PD
    Gdap2-PE
    Gdap2-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7716807..7735622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165553.5 → NP_724598.1  Gdap2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724598.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z741
      Related
      FBpp0088010
      Conserved Domains (1) summary
      pfam13716
      Location:97 → 228
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    2. NM_165554.4 → NP_724599.1  Gdap2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724599.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z742, C9QPK4
      Related
      FBpp0088011
      Conserved Domains (1) summary
      pfam13716
      Location:70 → 201
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    3. NM_001273860.2 → NP_001260789.1  Gdap2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260789.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEL9, C9QPK4
      Conserved Domains (1) summary
      pfam13716
      Location:70 → 193
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    4. NM_165552.5 → NP_724597.1  Gdap2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724597.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JUR6
      Related
      FBpp0088009
      Conserved Domains (3) summary
      COG2110
      Location:67 → 234
      YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
      cd02905
      Location:67 → 207
      Macro_GDAP2_like; Macro domain, GDAP2_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
      pfam13716
      Location:393 → 518
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    5. NM_001273861.2 → NP_001260790.1  Gdap2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFB9
      Conserved Domains (3) summary
      COG2110
      Location:67 → 234
      YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
      cd02905
      Location:67 → 207
      Macro_GDAP2_like; Macro domain, GDAP2_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
      pfam13716
      Location:387 → 512
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    6. NM_001259262.2 → NP_001246191.1  Gdap2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246191.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z396
      Conserved Domains (1) summary
      pfam13716
      Location:117 → 248
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEL9 A0A0B4KEL9
    A0A0B4KFB9 A0A0B4KFB9
    A1Z741 A1Z741
    A1Z742 A1Z742
    D1Z396 D1Z396
    Q7JUR6.1 Q7JUR6

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