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    GstE2 Glutathione S transferase E2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37107, updated on 10-May-2024

    Summary

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    Official Symbol
    GstE2provided by FlyBase
    Official Full Name
    Glutathione S transferase E2provided by FlyBase
    Primary source
    FLYBASE:FBgn0063498
    Locus tag
    Dmel_CG17523
    See related
    AllianceGenome:FB:FBgn0063498
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17523; Dmel\CG17523; DmGSTE2; gste2; GSTE2
    Summary
    Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See GstE2 in Genome Data Viewer
    Location:
    55C6-55C7; 2-85 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18399486..18400375)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14286991..14287880)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Imaginal disc growth factor 5 Neighboring gene Glutathione S transferase E10 Neighboring gene Glutathione S transferase E1 Neighboring gene Glutathione S transferase E3 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site. Wongsantichon J, et al. Biosci Rep, 2015 Oct 20. PMID 26487708, Free PMC Article
    2. The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans. Kislukhin G, et al. G3 (Bethesda), 2013 Aug 7. PMID 23733889, Free PMC Article
    3. Cloning, expression and biochemical characterization of one Epsilon-class (GST-3) and ten Delta-class (GST-1) glutathione S-transferases from Drosophila melanogaster, and identification of additional nine members of the Epsilon class. Sawicki R, et al. Biochem J, 2003 Mar 1. PMID 12443531, Free PMC Article
    4. Expression Patterns of Drosophila Melanogaster Glutathione Transferases. Gonis E, et al. Insects, 2022 Jul 7. PMID 35886788, Free PMC Article
    5. Evolutionary and structural analyses of GDAP1, involved in Charcot-Marie-Tooth disease, characterize a novel class of glutathione transferase-related genes. Marco A, et al. Mol Biol Evol, 2004 Jan. PMID 14595091

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase E2
    Names
    CG17523-PA
    GstE2-PA
    NP_611324.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18399486..18400375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137480.4 → NP_611324.1  glutathione S transferase E2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611324.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JYZ9
      Related
      FBpp0085851
      Conserved Domains (3) summary
      cd03177
      Location:94 → 209
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:5 → 196
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03045
      Location:5 → 78
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JYZ9 Q7JYZ9

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