daw dawdle [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dawprovided by FlyBase
Official Full Name: dawdleprovided by FlyBase
Primary source: FLYBASE:FBgn0031461
Locus tag: Dmel_CG16987
See related: AllianceGenome:FB:FBgn0031461
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Alp; Alp23b; Alp23B; ALP23B; cg16987; CG16987; Daw; DAW; Dmel\CG16987
Summary: Enables hormone activity. Involved in several processes, including cellular response to glucose stimulus; generation of neurons; and regulation of imaginal disc-derived wing size. Predicted to be active in extracellular space. Is expressed in several structures, including embryonic/larval central nervous system; epidermis; fat body; gonad; and gut. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Camurati-Engelmann disease; artery disease (multiple); colorectal cancer (multiple); and lung disease (multiple). Orthologous to human NODAL (nodal growth differentiation factor); TGFB1 (transforming growth factor beta 1); and TGFB2 (transforming growth factor beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 23B1-23B2; 2-7 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2805261..2812376)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2805261..2812376)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Dawdle causes major alterations in larval metabolic activity, including accumulation of tricarboxylic acid cycle intermediates, acidification of hemolymph, and misregulation of insulin signaling and nuclear-encoded mitochondrial gene expression.
Title: Systemic Activin signaling independently regulates sugar homeostasis, cellular metabolism, and pH balance in Drosophila melanogaster.
dawdle is activated by Gram-positive bacterial infection but repressed by Gram-negative infection or wounding; its role is to limit infection-induced melanization. Flies lacking dawdle function exhibit melanization even when uninfected.
Title: Multiple TGF-β superfamily signals modulate the adult Drosophila immune response.
Study shows that the Daw/Babo pathway acts upstream of gbb, and is involved in maintenance of muscle gbb expression.
Title: Activin signaling functions upstream of Gbb to regulate synaptic growth at the Drosophila neuromuscular junction.
Dawdle, one of four Activin-type ligands in Drosophila, preferentially signals through Babo(c), one of three isoforms of the Activin Type-I receptor that are expressed during development.
Title: The Drosophila Activin-like ligand Dawdle signals preferentially through one isoform of the Type-I receptor Baboon.
These results suggest that the Activin signaling pathway is required for producing the proper number of neurons to enable normal connection of incoming photoreceptor axons to their targets.
Title: Drosophila Activin- and the Activin-like product Dawdle function redundantly to regulate proliferation in the larval brain.
Results indicate that Daw functions in a permissive manner to modulate or enable the growth cone response to other restricted guidance cues, and support a novel role for activin signaling in axon guidance.
Title: The divergent TGF-beta ligand Dawdle utilizes an activin pathway to influence axon guidance in Drosophila.
Study suggests that by activating Daw and perhaps other TGF-beta ligands, tolloid related provides a permissive signal for axon guidance.
Title: The metalloprotease tolloid-related and its TGF-beta-like substrate Dawdle regulate Drosophila motoneuron axon guidance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0167 (e-PCR)
- UniSTS:5828

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in R8 cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in activin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in activin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to nutrient levels	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of imaginal disc-derived wing size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structure or activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: dawdle

Names: Activin-Like protein; CG16987-PA; CG16987-PB; CG16987-PC; DmDawdle; activin like protein; activin like protein at 23B; dActivin2; daw-PA; daw-PB; daw-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

2805261..2812376

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273038.1 → NP_001259967.1 dawdle, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259967.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VQG9

Conserved Domains (2) summary

pfam00019
Location:481 → 585

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:244 → 458

TGFb_propeptide; TGF-beta propeptide
NM_164503.2 → NP_722840.1 dawdle, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722840.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VQG9

Related

FBpp0077404

Conserved Domains (2) summary

pfam00019
Location:481 → 585

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:244 → 458

TGFb_propeptide; TGF-beta propeptide
NM_078737.3 → NP_523461.1 dawdle, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523461.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VQG9

Related

FBpp0077405

Conserved Domains (2) summary

pfam00019
Location:481 → 585

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:244 → 458

TGFb_propeptide; TGF-beta propeptide