Dolpp1 dolichyl pyrophosphate phosphatase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dolpp1provided by MGI
Official Full Name: dolichyl pyrophosphate phosphatase 1provided by MGI
Primary source: MGI:MGI:1914093
See related: Ensembl:ENSMUSG00000026856 AllianceGenome:MGI:1914093
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LSFR2; 0610011H20Rik
Summary: Enables dolichyldiphosphatase activity. Involved in protein N-linked glycosylation. Is integral component of endoplasmic reticulum membrane. Is expressed in alimentary system; liver; nervous system; respiratory system; and urinary system. Orthologous to human DOLPP1 (dolichyldiphosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in large intestine adult (RPKM 22.0), duodenum adult (RPKM 19.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 21.68 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (30282261..30290539)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (30392254..30400529)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results support a role for dolichyl pyrophosphate (Dol-P-P) phosphatase (Dolpp1) in the recycling of Dol-P-P discharged during protein N-glycosylation reactions on the luminal leaflet of the endoplasmic reticulum in mammalian cells [Dolpp1].
Title: Identification and characterization of a cDNA encoding a dolichyl pyrophosphate phosphatase located in the endoplasmic reticulum of mammalian cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dolichyldiphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyldiphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dolichyldiphosphatase 1

Names: protein 2-23

NP_001277437.1

EC 3.6.1.43

NP_001277438.1

EC 3.6.1.43

NP_065062.1

EC 3.6.1.43

XP_006498270.1

EC 3.6.1.43

XP_030107771.1

EC 3.6.1.43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290508.2 → NP_001277437.1 dolichyldiphosphatase 1 isoform b

See identical proteins and their annotated locations for NP_001277437.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an additional exon in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AL954388

Consensus CDS

CCDS71022.1

UniProtKB/TrEMBL

A0A140T8S3

Related

ENSMUSP00000119478.3, ENSMUST00000123202.8

Conserved Domains (1) summary

cl00474
Location:1 → 82

PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
NM_001290509.2 → NP_001277438.1 dolichyldiphosphatase 1 isoform c

See identical proteins and their annotated locations for NP_001277438.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.

Source sequence(s)

AL954388

Consensus CDS

CCDS79768.1

UniProtKB/TrEMBL

A2AWJ3

Related

ENSMUSP00000109242.4, ENSMUST00000113612.10

Conserved Domains (1) summary

cd03382
Location:16 → 154

PAP2_dolichyldiphosphatase; PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is ...
NM_020329.5 → NP_065062.1 dolichyldiphosphatase 1 isoform a

See identical proteins and their annotated locations for NP_065062.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AL954388

Consensus CDS

CCDS15881.1

UniProtKB/Swiss-Prot

Q8BN02, Q8R0P7, Q9CRF2, Q9JMF7

Related

ENSMUSP00000028209.9, ENSMUST00000028209.15

Conserved Domains (2) summary

COG0671
Location:9 → 184

PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]

cd03382
Location:16 → 180

PAP2_dolichyldiphosphatase; PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is ...

RNA

NR_110963.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks three internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL954388

Related

ENSMUST00000137248.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

30282261..30290539

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498207.5 → XP_006498270.1 dolichyldiphosphatase 1 isoform X1

See identical proteins and their annotated locations for XP_006498270.1

UniProtKB/TrEMBL

A0A140T8S3

Conserved Domains (1) summary

cl00474
Location:1 → 82

PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
XM_030251911.2 → XP_030107771.1 dolichyldiphosphatase 1 isoform X1

UniProtKB/TrEMBL

A0A140T8S3

Conserved Domains (1) summary

cl00474
Location:1 → 82

PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...