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    AT1G80360 Pyridoxal phosphate (PLP)-dependent transferases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844376, updated on 16-Jan-2024

    Summary

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    Gene symbol
    AT1G80360
    Gene description
    Pyridoxal phosphate (PLP)-dependent transferases superfamily protein
    Primary source
    Araport:AT1G80360
    Locus tag
    AT1G80360
    See related
    TAIR:AT1G80360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F5I6.11; F5I6_11; reversal of sav3 phenotype 1; VAS1
    Summary
    Encodes a methionine-specific aminotransferase that uses the ethylene biosynthetic intermediate methionine as an amino donor and the auxin biosynthetic intermediate indole-3-pyruvic acid as an amino acceptor to produce L-tryptophan and 2-oxo-4-methylthiobutyric acid. These actions allow VAS1 to coordinate both auxin and ethylene biosynthesis. It functions downstream of TAA1/SAV3 but upstream of YUCs to negatively modulate IAA biosynthesis directly by altering the 3-IPA pool.
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    Genomic context

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    See AT1G80360 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (30208408..30211592, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene gibberellin 3-oxidase 2 Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene Cyclin A2;4 Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Auxin and Tryptophan Homeostasis Are Facilitated by the ISS1/VAS1 Aromatic Aminotransferase in Arabidopsis. Pieck M, et al. Genetics, 2015 Sep. PMID 26163189, Free PMC Article
    2. Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1. Zheng Z, et al. Nat Chem Biol, 2013 Apr. PMID 23377040, Free PMC Article
    3. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
    4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cytosolic aminotransferase VAS1 coordinates aromatic amino acid biosynthesis and metabolism.
      Title: The cytosolic aminotransferase VAS1 coordinates aromatic amino acid biosynthesis and metabolism.
    2. Results suggest that ISS1 has a role in tryptophan (trp) catabolism and possibly in the metabolism of other aromatic amino acids. The loss of Trp catabolism impacts the use of Trp-D and/or Trp-I IAA synthesis pathways.
      Title: Auxin and Tryptophan Homeostasis Are Facilitated by the ISS1/VAS1 Aromatic Aminotransferase in Arabidopsis.
    3. Arabidopsis thaliana aminotransferase VAS1 coordinates biosynthesis of auxin and ethylene. [VAS1]
      Title: Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001334980.1
    NM_001334981.1
    NM_106685.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-tryptophan:2-oxoglutarate aminotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-tyrosine:2-oxoglutarate aminotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine-oxo-acid transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within auxin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in auxin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methionine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of ethylene biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of indoleacetic acid biosynthetic process via tryptophan IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within shade avoidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Pyridoxal phosphate (PLP)-dependent transferases superfamily protein
    NP_178152.1
    • Pyridoxal phosphate (PLP)-dependent transferases superfamily protein; FUNCTIONS IN: transferase activity, transferring nitrogenous groups, pyridoxal phosphate binding, transaminase activity, catalytic activity; INVOLVED IN: asparagine catabolic process, biosynthetic process, glutamate catabolic process to oxaloacetate, aspartate transamidation; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Aminotransferase, class I/classII (InterPro:IPR004839), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferases, class-I, pyridoxal-phosphate-binding site (InterPro:IPR004838), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: aspartate aminotransferase (TAIR:AT2G22250.1); Has 39039 Blast hits to 39038 proteins in 3030 species: Archae - 1022; Bacteria - 27880; Metazoa - 604; Fungi - 771; Plants - 1310; Viruses - 0; Other Eukaryotes - 7452 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30208408..30211592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001334979.1 → NP_001322147.1  Pyridoxal phosphate (PLP)-dependent transferases superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C969
      UniProtKB/TrEMBL
      A0A178WAK1, A0A5S9WW40
      Conserved Domains (1) summary
      PRK05957
      Location:17 → 388
      PRK05957; pyridoxal phosphate-dependent aminotransferase

    2. NM_106685.5 → NP_178152.1  Pyridoxal phosphate (PLP)-dependent transferases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178152.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C969
      UniProtKB/TrEMBL
      A0A178WAK1, A0A5S9WW40
      Conserved Domains (1) summary
      PRK05957
      Location:17 → 388
      PRK05957; pyridoxal phosphate-dependent aminotransferase

    3. NM_001334980.1 → NP_001322148.1  Pyridoxal phosphate (PLP)-dependent transferases superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C969
      UniProtKB/TrEMBL
      A0A178WAK1, A0A5S9WW40
      Conserved Domains (1) summary
      PRK05957
      Location:17 → 388
      PRK05957; pyridoxal phosphate-dependent aminotransferase

    4. NM_001334981.1 → NP_001322149.1  Pyridoxal phosphate (PLP)-dependent transferases superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C969
      UniProtKB/TrEMBL
      A0A178WAK1, A0A5S9WW40
      Conserved Domains (1) summary
      PRK05957
      Location:17 → 388
      PRK05957; pyridoxal phosphate-dependent aminotransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C969.1

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