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    Ftx Ftx transcript, Xist regulator, non-protein coding [ Mus musculus (house mouse) ]

    Gene ID: 78878, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ftxprovided by MGI
    Official Full Name
    Ftx transcript, Xist regulator, non-protein codingprovided by MGI
    Primary source
    MGI:MGI:1926128
    See related
    Ensembl:ENSMUSG00000086370 AllianceGenome:MGI:1926128
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Thcytx; NCRNA00182; B230206F22Rik
    Summary
    Acts upstream of or within chromatin organization; regulation of DNA methylation; and regulation of dosage compensation by inactivation of X chromosome. Is expressed in early conceptus. Orthologous to human FTX (FTX transcript, XIST regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 7.9), cortex adult (RPKM 6.7) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ftx in Genome Data Viewer
    Location:
    X D; X 46.21 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (102604516..102667360, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (103560910..103623754, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene estrogen receptor-binding fragment-associated gene 9 pseudogene Neighboring gene predicted gene, 53177 Neighboring gene STARR-seq mESC enhancer starr_47698 Neighboring gene microRNA 374b Neighboring gene microRNA 374c Neighboring gene microRNA 421 Neighboring gene STARR-seq mESC enhancer starr_47699 Neighboring gene predicted gene 9159 Neighboring gene STARR-positive B cell enhancer ABC_E5733 Neighboring gene zinc finger, CCHC domain containing 13 Neighboring gene predicted gene 53059 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype. Hosoi Y, et al. Nat Commun, 2018 Sep 20. PMID 30237402, Free PMC Article
    2. The Ftx Noncoding Locus Controls X Chromosome Inactivation Independently of Its RNA Products. Furlan G, et al. Mol Cell, 2018 May 3. PMID 29706539
    3. Parental-to-embryo switch of chromosome organization in early embryogenesis. Collombet S, et al. Nature, 2020 Apr. PMID 32238933
    4. Long Noncoding RNA FTX Reduces Hypertrophy of Neonatal Mouse Cardiac Myocytes and Regulates the PTEN/PI3K/Akt Signaling Pathway by Sponging MicroRNA-22. Yang X, et al. Med Sci Monit, 2019 Dec 16. PMID 31840653, Free PMC Article
    5. The lncRNA Ftx/miR-382-5p/Nrg1 axis improves the inflammation response of microglia and spinal cord injury repair. Xiang W, et al. Neurochem Int, 2021 Feb. PMID 33359189

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The lncRNA Ftx/miR-382-5p/Nrg1 axis improves the inflammation response of microglia and spinal cord injury repair.
      Title: The lncRNA Ftx/miR-382-5p/Nrg1 axis improves the inflammation response of microglia and spinal cord injury repair.
    2. The mechanism of action of lnc-FTX in neonatal mouse cardiac myocytes was through suppression of the PI3K/Akt signaling pathway by promoting the release of PTEN by sponging miRNA-22.
      Title: Long Noncoding RNA FTX Reduces Hypertrophy of Neonatal Mouse Cardiac Myocytes and Regulates the PTEN/PI3K/Akt Signaling Pathway by Sponging MicroRNA-22.
    3. loss-of-Ftx lncRNA abolishes gene silencing on the inactive X chromosome, leading to a female microphthalmia-like phenotype.
      Title: Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype.
    4. Ftx is a positive regulator of Xist and lead us to propose that Ftx is a novel ncRNA involved in XCI.
      Title: Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Other Names

    • thrombocytosis, familial X-linked

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gene expression via chromosomal CpG island demethylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within random inactivation of X chromosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within random inactivation of X chromosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_028380.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AA189299, AK035525, BC076616, BP758350
      Related
      ENSMUST00000156211.8

    2. NR_028381.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon and uses a distinct 3' splice pattern, compared to variant 1.
      Source sequence(s)
      AK035525
      Related
      ENSMUST00000130063.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      102604516..102667360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.