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    PRMT10 protein arginine methyltransferase 10 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839393, updated on 15-Oct-2023

    Summary

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    Gene symbol
    PRMT10
    Gene description
    protein arginine methyltransferase 10
    Primary source
    Araport:AT1G04870
    Locus tag
    AT1G04870
    See related
    TAIR:AT1G04870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPRMT10; F13M7.14; F13M7_14; protein arginine methyltransferase 10
    Summary
    Encodes a type I protein arginine methyltransferase based on the At1g04870.2 gene model. PRMT10 can catalyze the asymmetric dimethylation of arginine 3 on histone 4 and can also methylate myelin basic protein in vitro. Mutants lacking PRMT10 flower late due to defects in the autonomous pathway and they have elevated levels of FLC transcripts.
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    Genomic context

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    See PRMT10 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (1373234..1375821, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ubiquitin-associated (UBA)/TS-N domain-containing protein Neighboring gene ubiquitin-specific protease 2 Neighboring gene HMG (high mobility group) box protein with ARID/BRIGHT DNA-binding domain-containing protein Neighboring gene zein-binding protein (Protein of unknown function, DUF593)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of flowering time by the protein arginine methyltransferase AtPRMT10. Niu L, et al. EMBO Rep, 2007 Dec. PMID 18007657, Free PMC Article
    2. The enzymatic activity of Arabidopsis protein arginine methyltransferase 10 is essential for flowering time regulation. Niu L, et al. Protein Cell, 2012 Jun. PMID 22729397, Free PMC Article
    3. Redundant requirement for a pair of PROTEIN ARGININE METHYLTRANSFERASE4 homologs for the proper regulation of Arabidopsis flowering time. Niu L, et al. Plant Physiol, 2008 Sep. PMID 18660432, Free PMC Article
    4. Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes. Elrouby N, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20855607, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The methyltransferase activity of AtPRMT10 is essential for repressing FLC expression and promoting flowering in Arabidopsis.
      Title: The enzymatic activity of Arabidopsis protein arginine methyltransferase 10 is essential for flowering time regulation.
    2. Data show that genetic disruption of AtPRMT10 resulted in late flowering by upregulating FLOWERING LOCUS C (FLC) transcript levels. [AtPRMT10]
      Title: Regulation of flowering time by the protein arginine methyltransferase AtPRMT10.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_100365.4
    NM_179260.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone H4R3 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein-arginine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-arginine omega-N asymmetric methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-arginine omega-N monomethyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    protein arginine methyltransferase 10
    NP_563720.1
    • protein arginine methyltransferase 10 (PRMT10); FUNCTIONS IN: histone-arginine N-methyltransferase activity, methyltransferase activity, protein-arginine omega-N asymmetric methyltransferase activity, [myelin basic protein]-arginine N-methyltransferase activity, protein-arginine omega-N monomethyltransferase activity; INVOLVED IN: vegetative to reproductive phase transition of meristem, peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; LOCATED IN: cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Skb1 methyltransferase (InterPro:IPR007857); BEST Arabidopsis thaliana protein match is: protein arginine methyltransferase 6 (TAIR:AT3G20020.1); Has 3346 Blast hits to 3335 proteins in 890 species: Archae - 50; Bacteria - 1167; Metazoa - 1181; Fungi - 251; Plants - 354; Viruses - 1; Other Eukaryotes - 342 (source: NCBI BLink).
    NP_849591.1
    • protein arginine methyltransferase 10 (PRMT10); FUNCTIONS IN: methyltransferase activity; INVOLVED IN: vegetative to reproductive phase transition of meristem; LOCATED IN: cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Skb1 methyltransferase (InterPro:IPR007857); BEST Arabidopsis thaliana protein match is: protein arginine methyltransferase 6 (TAIR:AT3G20020.1); Has 1641 Blast hits to 1634 proteins in 326 species: Archae - 0; Bacteria - 17; Metazoa - 883; Fungi - 244; Plants - 262; Viruses - 0; Other Eukaryotes - 235 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1373234..1375821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100365.4 → NP_563720.1  protein arginine methyltransferase 10 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563720.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8W552, Q93Z15, Q9MAT5
      UniProtKB/TrEMBL
      A0A178WKU5, A0A5S9SMG0, A0A654E838
      Conserved Domains (1) summary
      cd02440
      Location:73 → 173
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_179260.1 → NP_849591.1  protein arginine methyltransferase 10 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849591.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9MAT5
      Conserved Domains (1) summary
      pfam12847
      Location:1 → 69
      Methyltransf_18; Methyltransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MAT5.1

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