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    Zfp292 zinc finger protein 292 [ Mus musculus (house mouse) ]

    Gene ID: 30046, updated on 8-May-2024

    Summary

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    Official Symbol
    Zfp292provided by MGI
    Official Full Name
    zinc finger protein 292provided by MGI
    Primary source
    MGI:MGI:1353423
    See related
    Ensembl:ENSMUSG00000039967 AllianceGenome:MGI:1353423
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp15; Zn-15; Zn-16; Zfp-15; Krox-10; mKIAA0530; 5730450D02Rik; 5830493J20Rik; 9430062L07Rik
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; genitourinary system; and spinal cord. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human ZNF292 (zinc finger protein 292). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.0), CNS E14 (RPKM 5.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp292 in Genome Data Viewer
    Location:
    4 A5; 4 16.86 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (34803110..34882982, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (34803110..34882983, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09916 Neighboring gene STARR-seq mESC enhancer starr_09917 Neighboring gene small integral membrane protein 8 Neighboring gene predicted gene, 57497 Neighboring gene STARR-positive B cell enhancer mm9_chr4:34767165-34767465 Neighboring gene tubulin, beta 6 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09922 Neighboring gene STARR-seq mESC enhancer starr_09925 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:34833884-34833993 Neighboring gene STARR-seq mESC enhancer starr_09928 Neighboring gene STARR-seq mESC enhancer starr_09932 Neighboring gene glycoprotein hormones, alpha subunit Neighboring gene pluripotency associated transcript 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Growth hormone transcription factor ZN-16 genomic coding regions are composed of a single exon and are evolutionarily conserved in mammals. Flynn MP, et al. Gene, 2006 Mar 1. PMID 16303260
    2. Transcript abundance in mouse pituitaries with altered growth hormone expression quantified by reverse transcriptase polymerase chain reaction implicates transcription factor Zn-16 in gene regulation in vivo. Wojtkiewicz PW, et al. Endocrine, 2002 Jun. PMID 12166626
    3. Mouse growth hormone transcription factor Zn-16: unique bipartite structure containing tandemly repeated zinc finger domains not reported in rat Zn-15. VanderHeyden TC, et al. Mol Cell Endocrinol, 2000 Jan 25. PMID 10687855
    4. Chromosomal localization of the zinc finger protein 15, Zfp15, on mouse chromosome 4. Roller ML, et al. Mamm Genome, 1995 Apr. PMID 7613041
    5. New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo. Heyer BS, et al. Mol Reprod Dev, 1997 Jun. PMID 9136115

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study shows that long noncoding RNA Kdm2b expression sustains the maintenance of Innate lymphoid cells by promoting their proliferation through activation of the transcription factor Zfp292
      Title: Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression.
    2. first in vivo evidence that Zn-16 mRNA abundance correlates with growth hormone expression
      Title: Transcript abundance in mouse pituitaries with altered growth hormone expression quantified by reverse transcriptase polymerase chain reaction implicates transcription factor Zn-16 in gene regulation in vivo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 292
    Names
    zinc finger protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429838.1 → NP_001416767.1  zinc finger protein 292 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX465850, BX649603

    2. NM_013889.3 → NP_038917.2  zinc finger protein 292 isoform 1

      See identical proteins and their annotated locations for NP_038917.2

      Status: VALIDATED

      Source sequence(s)
      BX465850, BX649603
      Consensus CDS
      CCDS51138.1
      UniProtKB/Swiss-Prot
      B1B0E1, B1B0E2, Q8BQX3, Q8BS87, Q8CGI6, Q922D3, Q9Z2U2
      Related
      ENSMUSP00000037233.6, ENSMUST00000047950.6
      Conserved Domains (3) summary
      COG5189
      Location:1758 → 1944
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:724 → 744
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:542 → 561
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      34803110..34882982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164179.1 → XP_036020072.1  zinc finger protein 292 isoform X1

      Conserved Domains (3) summary
      COG5189
      Location:1736 → 1922
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:702 → 722
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:520 → 539
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_036164180.1 → XP_036020073.1  zinc finger protein 292 isoform X1

      Conserved Domains (3) summary
      COG5189
      Location:1736 → 1922
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:702 → 722
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:520 → 539
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_036164181.1 → XP_036020074.1  zinc finger protein 292 isoform X2

      UniProtKB/TrEMBL
      Q8CHF2
      Conserved Domains (1) summary
      sd00017
      Location:734 → 757
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_006537978.5 → XP_006538041.1  zinc finger protein 292 isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:567 → 743
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:724 → 744
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:542 → 561
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2U2.2 GenPept UniProtKB/Swiss-Prot:Q9Z2U2

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