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    Fiz1 Flt3 interacting zinc finger protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 23877, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fiz1provided by MGI
    Official Full Name
    Flt3 interacting zinc finger protein 1provided by MGI
    Primary source
    MGI:MGI:1344336
    See related
    Ensembl:ENSMUSG00000061374 AllianceGenome:MGI:1344336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mFLJ00416
    Summary
    Enables receptor tyrosine kinase binding activity. Acts upstream of or within positive regulation of protein phosphorylation. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; brain ventricular layer; early conceptus; genitourinary system; and sensory organ. Orthologous to human FIZ1 (FLT3 interacting zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 19.0), ovary adult (RPKM 16.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fiz1 in Genome Data Viewer
    Location:
    7 A1; 7 2.9 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (5010055..5017727, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (5007056..5014728, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 579 Neighboring gene predicted gene, 53351 Neighboring gene STARR-seq mESC enhancer starr_17950 Neighboring gene zinc finger protein 524 Neighboring gene STARR-positive B cell enhancer ABC_E4889 Neighboring gene zinc finger protein 865

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells. Yee KW, et al. Blood, 2004 Dec 15. PMID 15304385
    2. FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo. Mali RS, et al. BMC Mol Biol, 2008 Oct 14. PMID 18854042, Free PMC Article
    3. Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor. Mitton KP, et al. Hum Mol Genet, 2003 Feb 15. PMID 12566383
    4. Fiz1, a novel zinc finger protein interacting with the receptor tyrosine kinase Flt3. Wolf I, et al. J Biol Chem, 1999 Jul 23. PMID 10409713
    5. Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas. Tsuruyama T, et al. J Leukoc Biol, 2010 Jul. PMID 20360400

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FLT3 and CD43 signaling pathways involve STAT5A via Fiz1 and Hipk2 in B lymphoblastic lymphomas.
      Title: Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas.
    2. Fiz1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo.
      Title: FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo.
    3. Addition of potent FLT3 inhibitors such as SU11248 to acute myeloid leukemia chemotherapy regimens could result in improved treatment results.
      Title: Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00416, MGC117900

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    flt3-interacting zinc finger protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110328.2 → NP_001103798.1  flt3-interacting zinc finger protein 1

      See identical proteins and their annotated locations for NP_001103798.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. All seven variants encode the same protein.
      Source sequence(s)
      AC157563
      Consensus CDS
      CCDS20751.1
      UniProtKB/Swiss-Prot
      Q91W14, Q9CTG3, Q9WTJ4
      UniProtKB/TrEMBL
      Q3TRV0, Q571H7
      Related
      ENSMUSP00000128105.2, ENSMUST00000165320.3
      Conserved Domains (2) summary
      sd00017
      Location:420 → 440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:432 → 457
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001110329.1 → NP_001103799.1  flt3-interacting zinc finger protein 1

      See identical proteins and their annotated locations for NP_001103799.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 5. All seven variants encode the same protein.
      Source sequence(s)
      AK142205, AW045450, CJ131593
      Consensus CDS
      CCDS20751.1
      UniProtKB/Swiss-Prot
      Q91W14, Q9CTG3, Q9WTJ4
      UniProtKB/TrEMBL
      Q3TRV0, Q571H7
      Related
      ENSMUSP00000076603.8, ENSMUST00000077385.15
      Conserved Domains (2) summary
      sd00017
      Location:420 → 440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:432 → 457
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001110330.1 → NP_001103800.1  flt3-interacting zinc finger protein 1

      See identical proteins and their annotated locations for NP_001103800.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 5. All seven variants encode the same protein.
      Source sequence(s)
      AK142205, AW045450, BU053482
      Consensus CDS
      CCDS20751.1
      UniProtKB/Swiss-Prot
      Q91W14, Q9CTG3, Q9WTJ4
      UniProtKB/TrEMBL
      Q3TRV0, Q571H7
      Related
      ENSMUSP00000147011.2, ENSMUST00000208944.2
      Conserved Domains (2) summary
      sd00017
      Location:420 → 440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:432 → 457
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001360241.1 → NP_001347170.1  flt3-interacting zinc finger protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the longest transcript. All seven variants encode the same protein.
      Source sequence(s)
      AC157563, BY203086
      Consensus CDS
      CCDS20751.1
      UniProtKB/Swiss-Prot
      Q91W14, Q9CTG3, Q9WTJ4
      UniProtKB/TrEMBL
      Q3TRV0, Q571H7
      Conserved Domains (2) summary
      sd00017
      Location:420 → 440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:432 → 457
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001360242.1 → NP_001347171.1  flt3-interacting zinc finger protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 5. All seven variants encode the same protein.
      Source sequence(s)
      AC157563, BC138232
      Consensus CDS
      CCDS20751.1
      UniProtKB/Swiss-Prot
      Q91W14, Q9CTG3, Q9WTJ4
      UniProtKB/TrEMBL
      Q3TRV0, Q571H7
      Related
      ENSMUSP00000147082.2, ENSMUST00000207030.2
      Conserved Domains (2) summary
      sd00017
      Location:420 → 440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:432 → 457
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001360243.1 → NP_001347172.1  flt3-interacting zinc finger protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 5. All seven variants encode the same protein.
      Source sequence(s)
      AC157563
      Consensus CDS
      CCDS20751.1
      UniProtKB/Swiss-Prot
      Q91W14, Q9CTG3, Q9WTJ4
      UniProtKB/TrEMBL
      Q3TRV0, Q571H7
      Conserved Domains (2) summary
      sd00017
      Location:420 → 440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:432 → 457
      zf-H2C2_2; Zinc-finger double domain

    7. NM_011813.3 → NP_035943.3  flt3-interacting zinc finger protein 1

      See identical proteins and their annotated locations for NP_035943.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 5. All seven variants encode the same protein.
      Source sequence(s)
      AC157563, AK142205, AW045450
      Consensus CDS
      CCDS20751.1
      UniProtKB/Swiss-Prot
      Q91W14, Q9CTG3, Q9WTJ4
      UniProtKB/TrEMBL
      Q3TRV0, Q571H7
      Related
      ENSMUSP00000126765.2, ENSMUST00000167804.9
      Conserved Domains (2) summary
      sd00017
      Location:420 → 440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:432 → 457
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      5010055..5017727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTJ4.1 GenPept UniProtKB/Swiss-Prot:Q9WTJ4

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