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    Jsrp1 junctional sarcoplasmic reticulum protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 71912, updated on 4-May-2024

    Summary

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    Official Symbol
    Jsrp1provided by MGI
    Official Full Name
    junctional sarcoplasmic reticulum protein 1provided by MGI
    Primary source
    MGI:MGI:1916700
    See related
    Ensembl:ENSMUSG00000020216 AllianceGenome:MGI:1916700
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    JP45; JP-45; 2300003C06Rik; 2310032K21Rik
    Summary
    Acts upstream of or within protein localization to membrane and regulation of ryanodine-sensitive calcium-release channel activity. Located in sarcoplasmic reticulum. Is expressed in skeletal muscle and tongue. Orthologous to human JSRP1 (junctional sarcoplasmic reticulum protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in mammary gland adult (RPKM 5.5), ovary adult (RPKM 5.4) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Jsrp1 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80644330..80649359, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80808494..80813741, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene splicing factor 3a, subunit 2 Neighboring gene Amh promoter region Neighboring gene anti-Mullerian hormone Neighboring gene STARR-seq mESC enhancer starr_27299 Neighboring gene STARR-positive B cell enhancer ABC_E369 Neighboring gene ornithine decarboxylase antizyme 1 Neighboring gene microRNA 1982 Neighboring gene leucine rich repeat and Ig domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging. Delbono O, et al. Exp Gerontol, 2012 Apr. PMID 22297108, Free PMC Article
    2. Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45. Delbono O, et al. Proc Natl Acad Sci U S A, 2007 Dec 11. PMID 18077436, Free PMC Article
    3. The junctional SR protein JP-45 affects the functional expression of the voltage-dependent Ca2+ channel Cav1.1. Anderson AA, et al. J Cell Sci, 2006 May 15. PMID 16638807, Free PMC Article
    4. Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow Twitch Skeletal Muscles. Mosca B, et al. J Biol Chem, 2016 Jul 8. PMID 27189940, Free PMC Article
    5. Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice. Mosca B, et al. Nat Commun, 2013. PMID 23443569, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Calcium entry activated by ablation of both JP45-CASQ1 and JP45-CASQ2 complexes supports tetanic force development in slow twitch soleus muscles.
      Title: Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow Twitch Skeletal Muscles.
    2. Ca(2+) transients evoked by tetanic stimulation are the result of massive Ca(2+) influx due to enhanced Ca(v)1.1 channel activity, which restores muscle strength in JP45/CASQ1 double knockout mice.
      Title: Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice.
    3. One of the molecules involved in the development or maintenance of skeletal muscle strength.
      Title: Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45.
    4. cloning, developmental expression, localization in sarcoplasmic reticulum, interaction with alpha 1.1 voltage-gated calcium channel, and involvement in skeletal muscle excitation-contraction coupling
      Title: The novel skeletal muscle sarcoplasmic reticulum JP-45 protein. Molecular cloning, tissue distribution, developmental expression, and interaction with alpha 1.1 subunit of the voltage-gated calcium channel.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ryanodine-sensitive calcium-release channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of ryanodine-sensitive calcium-release channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within striated muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sarcoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    junctional sarcoplasmic reticulum protein 1
    Names
    junctional-face membrane protein of 45 kDa homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028001.3 → NP_082277.2  junctional sarcoplasmic reticulum protein 1

      See identical proteins and their annotated locations for NP_082277.2

      Status: VALIDATED

      Source sequence(s)
      AC166937
      Consensus CDS
      CCDS24034.2
      UniProtKB/Swiss-Prot
      Q3MI48, Q9D755
      UniProtKB/TrEMBL
      M0QW57
      Related
      ENSMUSP00000137666.2, ENSMUST00000181039.8
      Conserved Domains (2) summary
      PRK14954
      Location:160 → 276
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional
      pfam15312
      Location:119 → 178
      JSRP; Junctional sarcoplasmic reticulum protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80644330..80649359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156028.1 → XP_036011921.1  junctional sarcoplasmic reticulum protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3MI48, Q9D755
      UniProtKB/TrEMBL
      M0QW57
      Conserved Domains (2) summary
      PRK14954
      Location:160 → 276
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional
      pfam15312
      Location:119 → 178
      JSRP; Junctional sarcoplasmic reticulum protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3MI48.2 GenPept UniProtKB/Swiss-Prot:Q3MI48

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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