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    APG1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825516, updated on 7-Sep-2023

    Summary

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    Gene symbol
    APG1
    Gene description
    S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
    Primary source
    Araport:AT3G63410
    Locus tag
    AT3G63410
    See related
    TAIR:AT3G63410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ALBINO OR PALE GREEN MUTANT 1; E37; IEP37; INNER ENVELOPE PROTEIN 37; VITAMIN E DEFECTIVE 3; VTE3
    Summary
    Encodes a MPBQ/MSBQ methyltransferase located in the chloroplast inner envelope membrane. Mutant plants lack plastoquinone (PQ), suggesting that the APG1 protein is involved in the methylation step of PQ biosynthesis. The gene product is also involved in tocopherol (vitamin E) biosynthesis.
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    Genomic context

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    See APG1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (23415589..23417119, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein Neighboring gene ncRNA Neighboring gene Ggamma-subunit 1 Neighboring gene zinc finger CCCH domain protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of the 37 kDa inner envelope membrane polypeptide in chloroplast biogenesis using a Ds-tagged Arabidopsis pale-green mutant. Motohashi R, et al. Plant J, 2003 Jun. PMID 12787252
    2. Highly divergent methyltransferases catalyze a conserved reaction in tocopherol and plastoquinone synthesis in cyanobacteria and photosynthetic eukaryotes. Cheng Z, et al. Plant Cell, 2003 Oct. PMID 14508009, Free PMC Article
    3. A split-ubiquitin yeast two-hybrid screen to examine the substrate specificity of atToc159 and atToc132, two Arabidopsis chloroplast preprotein import receptors. Dutta S, et al. PLoS One, 2014. PMID 24736607, Free PMC Article
    4. Proteomics of the chloroplast envelope membranes from Arabidopsis thaliana. Ferro M, et al. Mol Cell Proteomics, 2003 May. PMID 12766230
    5. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_116206.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 2-methyl-6-geranylgeranyl-1,4-benzoquinol methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-adenosylmethionine-dependent methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within plastoquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vitamin E biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vitamin E biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
    NP_191900.1
    • ALBINO OR PALE GREEN MUTANT 1 (APG1); FUNCTIONS IN: S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, 2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity; INVOLVED IN: plastoquinone biosynthetic process, vitamin E biosynthetic process; LOCATED IN: chloroplast, chloroplast inner membrane, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Methyltransferase type 11 (InterPro:IPR013216); Has 7919 Blast hits to 7917 proteins in 1885 species: Archae - 394; Bacteria - 5939; Metazoa - 115; Fungi - 139; Plants - 226; Viruses - 0; Other Eukaryotes - 1106 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      23415589..23417119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116206.3 → NP_191900.1  S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191900.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1EC48, Q8LDQ3, Q94IE2, Q9LY74
      UniProtKB/TrEMBL
      A0A178VHS6, A0A5S9XNA9, C0Z2G4
      Conserved Domains (1) summary
      PLN02490
      Location:1 → 338
      PLN02490; MPBQ/MSBQ methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LY74.1

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