Anp32b acidic nuclear phosphoprotein 32 family member B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Anp32bprovided by MGI
Official Full Name: acidic nuclear phosphoprotein 32 family member Bprovided by MGI
Primary source: MGI:MGI:1914878
See related: Ensembl:ENSMUSG00000028333 AllianceGenome:MGI:1914878
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAL31; Ssp29; PHAPI2a; 2410015B15Rik
Summary: Predicted to enable RNA polymerase binding activity and histone binding activity. Acts upstream of or within several processes, including inner ear development; roof of mouth development; and ventricular system development. Located in nucleus. Is expressed in several structures, including eye; heart; and metanephros. Orthologous to human ANP32B (acidic nuclear phosphoprotein 32 family member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14 (RPKM 62.7), liver E14.5 (RPKM 50.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 24.79 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (46450926..46472657)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (46450926..46472657)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase Adaptations in Avian Influenza Virus.
Title: Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase Adaptations in Avian Influenza Virus.
ANP32B suppresses B-cell acute lymphoblastic leukemia through activation of PU.1 in mice.
Title: ANP32B suppresses B-cell acute lymphoblastic leukemia through activation of PU.1 in mice.
ANP32B-mediated repression of p53 contributes to maintenance of normal and CML stem cells.
Title: ANP32B-mediated repression of p53 contributes to maintenance of normal and CML stem cells.
ANP32B Deficiency Protects Mice From Lethal Influenza A Virus Challenge by Dampening the Host Immune Response.
Title: ANP32B Deficiency Protects Mice From Lethal Influenza A Virus Challenge by Dampening the Host Immune Response.
The acidic protein rich in leucines Anp32b is an immunomodulator of inflammation in mice.
Title: The acidic protein rich in leucines Anp32b is an immunomodulator of inflammation in mice.
ANP32B deficiency downregulates AKT phosphorylation, which involves its regulating effect on cell growth. Collectively, findings suggest that ANP32B is an oncogene.
Title: ANP32B deficiency impairs proliferation and suppresses tumor progression by regulating AKT phosphorylation.
ANP32B is a widespread regulator of gene expression and has no apparent oncogenic role for this protein in mammary tumorigenesis.
Title: BALB/c-congenic ANP32B-deficient mice reveal a modifying locus that determines viability.
Data demonstrate a hierarchy of importance for the mammalian Anp32 genes, with Anp32b being the most critical for normal development.
Title: Acidic nuclear phosphoprotein 32kDa (ANP32)B-deficient mouse reveals a hierarchy of ANP32 importance in mammalian development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info	PubMed
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: acidic leucine-rich nuclear phosphoprotein 32 family member B

Names: acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; acidic protein rich in leucines; proliferation related acidic leucine rich protein PAL31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130889.3 → NP_570959.1 acidic leucine-rich nuclear phosphoprotein 32 family member B

See identical proteins and their annotated locations for NP_570959.1

Status: VALIDATED

Source sequence(s)

AK165807, CJ053476, CK623910

Consensus CDS

CCDS18151.1

UniProtKB/Swiss-Prot

B1AVH9, Q566J4, Q9EST5

Related

ENSMUSP00000099990.5, ENSMUST00000102926.5

Conserved Domains (3) summary

COG4886
Location:16 → 115

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00035
Location:90 → 113

LRR_NTF; leucine-rich repeat [structural motif]

pfam14580
Location:71 → 146

LRR_9; Leucine-rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

46450926..46472657

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250089.4 → XP_011248391.1 acidic leucine-rich nuclear phosphoprotein 32 family member B isoform X1

Conserved Domains (2) summary

sd00035
Location:61 → 84

LRR_NTF; leucine-rich repeat [structural motif]

pfam14580
Location:42 → 117

LRR_9; Leucine-rich repeat