Rab35 RAB35, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab35provided by MGI
Official Full Name: RAB35, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:1924657
See related: Ensembl:ENSMUSG00000029518 AllianceGenome:MGI:1924657
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RAY; H-ray; RAB1C; 9530019H02Rik
Summary: Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in neuron projection development. Located in mitochondrion. Is expressed in alimentary system; brain; genitourinary system; and lung. Orthologous to human RAB35 (RAB35, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 51.4), adrenal adult (RPKM 39.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.1 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (115769953..115785217)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (115631904..115647158)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAB35 is required for murine hippocampal development and functions by regulating neuronal cell distribution.
Title: RAB35 is required for murine hippocampal development and functions by regulating neuronal cell distribution.
miR-720 Regulates Insulin Secretion by Targeting Rab35.
Title: miR-720 Regulates Insulin Secretion by Targeting Rab35.
Rab35 and its effectors promote formation of tunneling nanotubes in neuronal cells.
Title: Rab35 and its effectors promote formation of tunneling nanotubes in neuronal cells.
Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth.
Title: Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth.
Results suggest that RAB35 GTPase has multiple roles in spindle stability and actin-mediated spindle migration in mouse oocyte meiosis.
Title: RAB35 depletion affects spindle formation and actin-based spindle migration in mouse oocyte meiosis.
These findings demonstrate roles for Rab35 in regulating cilium length.
Title: Rab35 controls cilium length, function and membrane composition.
A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.
Title: A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.
This study demonstrated that Rab35 regulates Cdc42 activity in neurons.
Title: Rab35 Functions in Axon Elongation Are Regulated by P53-Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule-Associated Protein 1B.
The Rab35 plays an important role in spindle organization and morphology maintenance, and thus meiotic nuclear maturation.
Title: Rab3A, Rab27A, and Rab35 regulate different events during mouse oocyte meiotic maturation and activation.
Rab35 regulates myoblast fusion, a major cellular process under the control of cadherin-dependent signaling.
Title: Rab35 regulates cadherin-mediated adherens junction formation and myoblast fusion.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235282

AU040256 (e-PCR)
- UniSTS:159433

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nerve growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane to endosome transport	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to endosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection membrane	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198163.1 → NP_937806.1 ras-related protein Rab-35

See identical proteins and their annotated locations for NP_937806.1

Status: PROVISIONAL

Source sequence(s)

BC056466

Consensus CDS

CCDS19596.1

UniProtKB/Swiss-Prot

Q6PHN9

UniProtKB/TrEMBL

Q3U0T9

Related

ENSMUSP00000031492.9, ENSMUST00000031492.15

Conserved Domains (1) summary

cd04110
Location:3 → 201

Rab35; Rab GTPase family 35 (Rab35)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

115769953..115785217

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530500.5 → XP_006530563.1 ras-related protein Rab-35 isoform X1

Conserved Domains (1) summary

cl38936
Location:3 → 117

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases