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    Cenatac centrosomal AT-AC splicing factor [ Mus musculus (house mouse) ]

    Gene ID: 382073, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cenatacprovided by MGI
    Official Full Name
    centrosomal AT-AC splicing factorprovided by MGI
    Primary source
    MGI:MGI:2685960
    See related
    Ensembl:ENSMUSG00000043923 AllianceGenome:MGI:2685960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc84; Gm1114; D630044F24Rik
    Summary
    Predicted to be involved in negative regulation of centrosome duplication and regulation of protein catabolic process. Predicted to be located in centrosome. Orthologous to human CENATAC (centrosomal AT-AC splicing factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 9.6), CNS E14 (RPKM 9.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cenatac in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44321456..44329390, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44410159..44418084, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 37 (glucose-6-phosphate transporter), member 4 Neighboring gene microRNA 7085 Neighboring gene STARR-positive B cell enhancer ABC_E2291 Neighboring gene trafficking protein particle complex 4 Neighboring gene ribosomal protein S25 Neighboring gene STARR-seq mESC enhancer starr_23968 Neighboring gene forkhead box R1 Neighboring gene uroplakin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106805

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal AT-AC splicing factor
    Names
    coiled-coil domain containing 84
    coiled-coil domain-containing protein 84

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201372.4 → NP_958760.2  centrosomal AT-AC splicing factor

      See identical proteins and their annotated locations for NP_958760.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AC122428
      Consensus CDS
      CCDS23110.1
      UniProtKB/Swiss-Prot
      Q3TAL6, Q4VA36, Q7TNQ4, Q8C702
      Related
      ENSMUSP00000053216.8, ENSMUST00000053286.9
      Conserved Domains (1) summary
      pfam14968
      Location:7 → 320
      CCDC84; Coiled coil protein 84

    RNA

    1. NR_151775.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC122428, AK052757

    2. NR_151776.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC122428
      Related
      ENSMUST00000214494.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44321456..44329390 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510472.4 → XP_006510535.1  centrosomal AT-AC splicing factor isoform X1

      Conserved Domains (1) summary
      pfam14968
      Location:7 → 329
      CCDC84; Coiled coil protein 84

    2. XM_036155094.1 → XP_036010987.1  centrosomal AT-AC splicing factor isoform X2

      Conserved Domains (1) summary
      pfam14968
      Location:7 → 246
      CCDC84; Coiled coil protein 84

    RNA

    1. XR_004935474.1 RNA Sequence

    2. XR_004935471.1 RNA Sequence

    3. XR_004935470.1 RNA Sequence

    4. XR_003947942.2 RNA Sequence

    5. XR_004935476.1 RNA Sequence

    6. XR_004935475.1 RNA Sequence

    7. XR_004935473.1 RNA Sequence

    8. XR_003947941.2 RNA Sequence

    9. XR_003947940.2 RNA Sequence

    10. XR_001778937.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4VA36.1 GenPept UniProtKB/Swiss-Prot:Q4VA36

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