Ccn6 cellular communication network factor 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccn6provided by MGI
Official Full Name: cellular communication network factor 6provided by MGI
Primary source: MGI:MGI:2685581
See related: Ensembl:ENSMUSG00000062074 AllianceGenome:MGI:2685581
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm735; Wisp3; WISP-3
Summary: Predicted to enable heparin binding activity and integrin binding activity. Predicted to be involved in several processes, including negative regulation of cell death; regulation of mitochondrial membrane potential; and regulation of reactive oxygen species biosynthetic process. Predicted to act upstream of or within negative regulation of angiogenesis and negative regulation of cell population proliferation. Predicted to be located in extracellular space and mitochondrion. Predicted to be active in extracellular matrix. Is expressed in embryo. Used to study breast metaplastic carcinoma and progressive pseudorheumatoid arthropathy of childhood. Human ortholog(s) of this gene implicated in progressive pseudorheumatoid arthropathy of childhood. Orthologous to human CCN6 (cellular communication network factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 11.6), CNS E11.5 (RPKM 4.9) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B1; 10 20.19 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (39026966..39049484, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (39150970..39174376, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WISP-3/CCN6 has a role in inhibiting apoptosis by regulating caspase pathway after hyperoxia in lung epithelial cells
Title: WISP-3/CCN6 inhibits apoptosis by regulating caspase pathway after hyperoxia in lung epithelial cells.
demonstrated that CCN6 induced the proliferation of lung fibroblasts by binding to integrin beta1, leading to the phosphorylation of FAK(Y397).
Title: CCN6 as a profibrotic mediator that stimulates the proliferation of lung fibroblasts via the integrin β1/focal adhesion kinase pathway.
the WISP3 gene is essential to skeletal growth or homeostasis in humans but not in mice [WISP3]
Title: WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

General gene information

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Markers

Wisp3 (e-PCR), detects polymorphism
- UniSTS:527129

Wisp3 (e-PCR), detects polymorphism
- UniSTS:532698

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cellular communication network factor 6

Names: CCN family member 6; WNT1 inducible signaling pathway protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127376.1 → NP_001120848.1 cellular communication network factor 6 precursor

See identical proteins and their annotated locations for NP_001120848.1

Status: VALIDATED

Source sequence(s)

AC153958

Consensus CDS

CCDS48537.1

UniProtKB/Swiss-Prot

D3Z5L9

Related

ENSMUSP00000076003.5, ENSMUST00000076713.6

Conserved Domains (3) summary

pfam00219
Location:48 → 100

IGFBP; Insulin-like growth factor binding protein

pfam19035
Location:209 → 252

TSP1_CCN; CCN3 Nov like TSP1 domain

cl21545
Location:275 → 341

GHB_like; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

39026966..39049484 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155821.1 → XP_036011714.1 cellular communication network factor 6 isoform X1

UniProtKB/Swiss-Prot

D3Z5L9

Conserved Domains (3) summary

pfam00219
Location:48 → 100

IGFBP; Insulin-like growth factor binding protein

pfam19035
Location:209 → 252

TSP1_CCN; CCN3 Nov like TSP1 domain

cl21545
Location:275 → 341

GHB_like; Glycoprotein hormone beta chain homologues
XM_030245127.2 → XP_030100987.1 cellular communication network factor 6 isoform X1

UniProtKB/Swiss-Prot

D3Z5L9

Conserved Domains (3) summary

pfam00219
Location:48 → 100

IGFBP; Insulin-like growth factor binding protein

pfam19035
Location:209 → 252

TSP1_CCN; CCN3 Nov like TSP1 domain

cl21545
Location:275 → 341

GHB_like; Glycoprotein hormone beta chain homologues
XM_036155822.1 → XP_036011715.1 cellular communication network factor 6 isoform X1

UniProtKB/Swiss-Prot

D3Z5L9

Conserved Domains (3) summary

pfam00219
Location:48 → 100

IGFBP; Insulin-like growth factor binding protein

pfam19035
Location:209 → 252

TSP1_CCN; CCN3 Nov like TSP1 domain

cl21545
Location:275 → 341

GHB_like; Glycoprotein hormone beta chain homologues