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    Eri2 exoribonuclease 2 [ Mus musculus (house mouse) ]

    Gene ID: 71151, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Eri2provided by MGI
    Official Full Name
    exoribonuclease 2provided by MGI
    Primary source
    MGI:MGI:1918401
    See related
    Ensembl:ENSMUSG00000030929 AllianceGenome:MGI:1918401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Exod1; mKIAA1504; 4933424N09Rik
    Summary
    Predicted to enable 3'-5'-exoribonuclease activity. Predicted to be involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Orthologous to human ERI2 (ERI1 exoribonuclease family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 4.7), limb E14.5 (RPKM 4.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eri2 in Genome Data Viewer
    Location:
    7 F2; 7 64.18 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119383049..119393283, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119783826..119794058, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene UPF0124 protein C13orf31 homolog Neighboring gene acyl-CoA synthetase medium-chain family member 3 Neighboring gene predicted gene, 57786 Neighboring gene RNA exonuclease 5 Neighboring gene STARR-seq mESC enhancer starr_20039 Neighboring gene defective in cullin neddylation 1 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E3747 Neighboring gene STARR-seq mESC enhancer starr_20040 Neighboring gene LYR motif containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ERI1 exoribonuclease 2
    Names
    exonuclease domain containing 1
    exonuclease domain-containing protein 1
    NP_001342033.1
    NP_081974.3
    XP_006508270.1
    XP_006508273.1
    XP_030098848.1
    XP_030098849.1
    XP_036009329.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355104.1 → NP_001342033.1  ERI1 exoribonuclease 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164158
      UniProtKB/TrEMBL
      Q6ZPP5
      Conserved Domains (1) summary
      pfam06839
      Location:364 → 412
      zf-GRF; GRF zinc finger

    2. NM_027698.5 → NP_081974.3  ERI1 exoribonuclease 2 isoform 1

      See identical proteins and their annotated locations for NP_081974.3

      Status: VALIDATED

      Source sequence(s)
      AC164158, AK165163, BY019377
      Consensus CDS
      CCDS40107.1
      UniProtKB/Swiss-Prot
      Q3TUK9, Q5BKS4, Q8C133
      Related
      ENSMUSP00000120547.2, ENSMUST00000150844.3
      Conserved Domains (2) summary
      cd06133
      Location:37 → 230
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
      pfam06839
      Location:592 → 640
      zf-GRF; GRF zinc finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      119383049..119393283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242989.2 → XP_030098849.1  ERI1 exoribonuclease 2 isoform X1

      UniProtKB/TrEMBL
      Q6ZPP5
      Conserved Domains (1) summary
      pfam06839
      Location:364 → 412
      zf-GRF; GRF zinc finger

    2. XM_030242988.2 → XP_030098848.1  ERI1 exoribonuclease 2 isoform X1

      UniProtKB/TrEMBL
      Q6ZPP5
      Conserved Domains (1) summary
      pfam06839
      Location:364 → 412
      zf-GRF; GRF zinc finger

    3. XM_006508207.4 → XP_006508270.1  ERI1 exoribonuclease 2 isoform X1

      See identical proteins and their annotated locations for XP_006508270.1

      UniProtKB/TrEMBL
      Q6ZPP5
      Conserved Domains (1) summary
      pfam06839
      Location:364 → 412
      zf-GRF; GRF zinc finger

    4. XM_036153436.1 → XP_036009329.1  ERI1 exoribonuclease 2 isoform X2

      UniProtKB/TrEMBL
      Q6ZPP5
      Conserved Domains (1) summary
      pfam06839
      Location:322 → 369
      zf-GRF; GRF zinc finger

    5. XM_006508210.5 → XP_006508273.1  ERI1 exoribonuclease 2 isoform X3

      UniProtKB/TrEMBL
      D3YW28
      Related
      ENSMUSP00000102133.2, ENSMUST00000106523.8
      Conserved Domains (1) summary
      cd06133
      Location:37 → 230
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    RNA

    1. XR_004934186.1 RNA Sequence

      Related
      ENSMUST00000139192.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BKS4.1 GenPept UniProtKB/Swiss-Prot:Q5BKS4

    Gene LinkOut

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