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    Pgc progastricsin (pepsinogen C) [ Mus musculus (house mouse) ]

    Gene ID: 109820, updated on 12-May-2024

    Summary

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    Official Symbol
    Pgcprovided by MGI
    Official Full Name
    progastricsin (pepsinogen C)provided by MGI
    Primary source
    MGI:MGI:98909
    See related
    Ensembl:ENSMUSG00000023987 AllianceGenome:MGI:98909
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Upg1; Upg-1; 2210410L06Rik
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in positive regulation of antibacterial peptide production. Predicted to act upstream of or within digestion and proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in stomach epithelium. Orthologous to human PGC (progastricsin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward duodenum adult (RPKM 123.5) See more
    Orthologs
    human all
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    Genomic context

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    See Pgc in Genome Data Viewer
    Location:
    17 C; 17 23.98 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48037767..48045403)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47726842..47734478)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42721 Neighboring gene fibroblast growth factor receptor substrate 3 Neighboring gene fibroblast growth factor receptor substrate 3, opposite strand Neighboring gene STARR-seq mESC enhancer starr_42724 Neighboring gene predicted gene, 46579 Neighboring gene STARR-positive B cell enhancer ABC_E10960 Neighboring gene STARR-positive B cell enhancer ABC_E5617 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47876786-47876895 Neighboring gene transcription factor EB Neighboring gene STARR-positive B cell enhancer ABC_E2491 Neighboring gene STARR-positive B cell enhancer ABC_E5618 Neighboring gene STARR-seq mESC enhancer starr_42729 Neighboring gene MyoD family inhibitor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The relationship between pepsinogen C and gastric carcinogenesis: a transgene and population study. E Y, et al. BMC Cancer, 2023 Jun 8. PMID 37291517, Free PMC Article
    2. Genetic variation of urinary pepsinogen and its probable linkage to albinism in the rat. Cramer DV. Immunogenetics, 1981. PMID 7287084
    3. Linkage of a gene controlling urinary pepsinogen with the major histocompatibility complex of the mouse. Szymura JM, et al. Immunogenetics, 1981. PMID 7275224
    4. Mapping of the mouse Upg-1 locus. Szymura JM, et al. Immunogenetics, 1982. PMID 7118213
    5. The alpha-globin pseudogene on mouse chromosome 17 is closely linked to H-2. D'Eustachio P, et al. J Exp Med, 1984 Mar 1. PMID 6321630, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The relationship between pepsinogen C and gastric carcinogenesis: a transgene and population study.
      Title: The relationship between pepsinogen C and gastric carcinogenesis: a transgene and population study.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117575

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within digestion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of antibacterial peptide production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gastricsin
    Names
    pepsinogen C
    urinary pepsinogen 1
    NP_080249.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025973.3 → NP_080249.2  gastricsin precursor

      See identical proteins and their annotated locations for NP_080249.2

      Status: PROVISIONAL

      Source sequence(s)
      AK008959
      Consensus CDS
      CCDS28855.1
      UniProtKB/Swiss-Prot
      Q9D7R7, Q9D7T2
      Related
      ENSMUSP00000024782.6, ENSMUST00000024782.12
      Conserved Domains (3) summary
      pfam00026
      Location:75 → 390
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:18 → 46
      A1_Propeptide; A1 Propeptide
      cl11403
      Location:73 → 391
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48037767..48045403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7R7.1 GenPept UniProtKB/Swiss-Prot:Q9D7R7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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