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    Pcsk4 proprotein convertase subtilisin/kexin type 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171085, updated on 2-May-2024

    Summary

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    Official Symbol
    Pcsk4provided by RGD
    Official Full Name
    proprotein convertase subtilisin/kexin type 4provided by RGD
    Primary source
    RGD:620325
    See related
    Ensembl:ENSRNOG00000016405 AllianceGenome:RGD:620325
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in peptide hormone processing; single fertilization; and sperm capacitation. Predicted to be located in acrosomal membrane. Predicted to be active in membrane and trans-Golgi network. Predicted to be integral component of Golgi membrane. Orthologous to human PCSK4 (proprotein convertase subtilisin/kexin type 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 79.4), Adrenal (RPKM 24.2) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcsk4 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10032040..10040263)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9381366..9389589)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12247498..12255721)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ADAMTS-like 5 Neighboring gene receptor accessory protein 6 Neighboring gene uncharacterized LOC108351405 Neighboring gene similar to human chromosome 19 open reading frame 25 Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene ribosomal protein S15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enzymatic activity of sperm proprotein convertase is important for mammalian fertilization. Iamsaard S, et al. J Cell Physiol, 2011 Nov. PMID 21302280
    2. PCSK4-null sperm display enhanced protein tyrosine phosphorylation and ADAM2 proteolytic processing during in vitro capacitation. Gyamera-Acheampong C, et al. Fertil Steril, 2010 Mar 1. PMID 19342015
    3. Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability. Gyamera-Acheampong C, et al. Biol Reprod, 2006 Apr. PMID 16371590
    4. Impaired fertility in mice deficient for the testicular germ-cell protease PC4. Mbikay M, et al. Proc Natl Acad Sci U S A, 1997 Jun 24. PMID 9192653, Free PMC Article
    5. Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase. Seidah NG, et al. Mol Endocrinol, 1992 Oct. PMID 1448111

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maturation by propeptide removal occurs very inefficiently when rat or human proPCSK4 is overexpressed in HEK293 cells.
      Title: The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosome reaction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within acrosome reaction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in acrosome reaction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in binding of sperm to zona pellucida IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in binding of sperm to zona pellucida ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fertilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptide hormone processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sperm capacitation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sperm capacitation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm capacitation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm capacitation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in acrosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in acrosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    proprotein convertase subtilisin/kexin type 4
    Names
    KEX2-like endoprotease 3
    NEC 3
    PC4
    neuroendocrine convertase 3
    prohormone convertase 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133559.1 → NP_598243.1  proprotein convertase subtilisin/kexin type 4 precursor

      See identical proteins and their annotated locations for NP_598243.1

      Status: PROVISIONAL

      Source sequence(s)
      L14937
      UniProtKB/TrEMBL
      A6K8M5, D3ZKU8
      Related
      ENSRNOP00000022358.5, ENSRNOT00000022358.8
      Conserved Domains (4) summary
      cd04059
      Location:115 → 404
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:146 → 419
      Peptidase_S8; Subtilase family
      pfam01483
      Location:488 → 567
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:34 → 110
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10032040..10040263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q78EH2.1 GenPept UniProtKB/Swiss-Prot:Q78EH2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools