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    Arfip1 ADP-ribosylation factor interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 99889, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Arfip1provided by MGI
    Official Full Name
    ADP-ribosylation factor interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1277120
    See related
    Ensembl:ENSMUSG00000074513 Ensembl:ENSMUSG00000102805 AllianceGenome:MGI:1277120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arfaptin; D3Ertd598e; 2310030I10Rik
    Summary
    Predicted to enable phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in intracellular protein transport; negative regulation of retrograde transport, endosome to Golgi; and regulation of Arp2/3 complex-mediated actin nucleation. Predicted to act upstream of or within regulation of protein secretion. Predicted to be located in Golgi membrane and cytosol. Predicted to be active in trans-Golgi network membrane. Orthologous to human ARFIP1 (ADP ribosylation factor interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 12.6), placenta adult (RPKM 11.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arfip1 in Genome Data Viewer
    Location:
    3 F1; 3 37.7 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (84403400..84490075, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (84496093..84582751, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930565D16 gene Neighboring gene STARR-seq mESC enhancer starr_08085 Neighboring gene FH2 domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:84346416-84346716 Neighboring gene high mobility group box 3 pseudogene Neighboring gene predicted gene, 35410 Neighboring gene tigger transposable element derived 4 Neighboring gene predicted gene, 46836

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    2. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    arfaptin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081093.2 → NP_001074562.1  arfaptin-1 isoform 1

      See identical proteins and their annotated locations for NP_001074562.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102224
      Consensus CDS
      CCDS38466.1
      UniProtKB/Swiss-Prot
      A2RSX9, E9Q3G5, G5E8V9
      Related
      ENSMUSP00000122964.2, ENSMUST00000143514.3
      Conserved Domains (1) summary
      cd07660
      Location:155 → 355
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    2. NM_001293801.1 → NP_001280730.1  arfaptin-1 isoform 2

      See identical proteins and their annotated locations for NP_001280730.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC102224
      Consensus CDS
      CCDS79931.1
      UniProtKB/TrEMBL
      A2RSX9
      Related
      ENSMUSP00000096588.4, ENSMUST00000098990.10
      Conserved Domains (1) summary
      cd07660
      Location:123 → 323
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      84403400..84490075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502484.4 → XP_006502547.1  arfaptin-1 isoform X3

      UniProtKB/TrEMBL
      E9QAY5, Q3TVE1
      Related
      ENSMUSP00000116393.2, ENSMUST00000154148.8
      Conserved Domains (1) summary
      cd07660
      Location:34 → 234
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    2. XM_036163483.1 → XP_036019376.1  arfaptin-1 isoform X2

      Conserved Domains (1) summary
      cd07660
      Location:123 → 323
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    3. XM_006502482.4 → XP_006502545.1  arfaptin-1 isoform X1

      See identical proteins and their annotated locations for XP_006502545.1

      UniProtKB/Swiss-Prot
      A2RSX9, E9Q3G5, G5E8V9
      Conserved Domains (1) summary
      cd07660
      Location:155 → 355
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5E8V9.1 GenPept UniProtKB/Swiss-Prot:G5E8V9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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