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    Senp5 SUMO/sentrin specific peptidase 5 [ Mus musculus (house mouse) ]

    Gene ID: 320213, updated on 12-May-2024

    Summary

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    Official Symbol
    Senp5provided by MGI
    Official Full Name
    SUMO/sentrin specific peptidase 5provided by MGI
    Primary source
    MGI:MGI:2443596
    See related
    Ensembl:ENSMUSG00000022772 AllianceGenome:MGI:2443596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SMT3IP3; 6230429P13Rik; A730063F07Rik
    Summary
    Predicted to enable SUMO-specific endopeptidase activity. Predicted to be involved in protein desumoylation. Predicted to act upstream of or within cell division. Predicted to be located in centrosome; cytosol; and nuclear lumen. Predicted to be active in nucleus. Is expressed in ganglia and heart. Orthologous to human SENP5 (SUMO specific peptidase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 6.7), CNS E11.5 (RPKM 4.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Senp5 in Genome Data Viewer
    Location:
    16 B2; 16 22.4 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31778488..31829388, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (31959670..32003287, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Ncbp2 antisense 2 (head to head) Neighboring gene nuclear cap binding protein subunit 2 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a), pseudogene Neighboring gene high mobility group box 1, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_40638 Neighboring gene p21 (RAC1) activated kinase 2 Neighboring gene predicted gene, 26419 Neighboring gene STARR-positive B cell enhancer ABC_E7439 Neighboring gene STARR-positive B cell enhancer ABC_E4164 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development. Yamada S, et al. iScience, 2021 Dec 17. PMID 34988397, Free PMC Article
    2. Synaptic localization of the SUMOylation-regulating protease SENP5 in the adult mouse brain. Akiyama H, et al. J Comp Neurol, 2018 Apr 15. PMID 29277914
    3. SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy. Kim EY, et al. J Mol Cell Cardiol, 2015 Jan. PMID 25128087
    4. SMT3IP1, a nucleolar SUMO-specific protease, deconjugates SUMO-2 from nucleolar and cytoplasmic nucleophosmin. Nishida T, et al. Biochem Biophys Res Commun, 2008 Sep 19. PMID 18639523
    5. Zinc deficiency induces abnormal development of the myocardium by promoting SENP5 overexpression. Zhang X, et al. PLoS One, 2020. PMID 33211757, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In the present study demonstrate for the first time that SENP5 are ubiquitously distributed in the adult murine brain.
      Title: Synaptic localization of the SUMOylation-regulating protease SENP5 in the adult mouse brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp564O1016

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deSUMOylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sentrin-specific protease 5
    Names
    SUMO/Smt3-specific isopeptidase 3
    SUMO/sentrin specific protease 5
    sentrin/SUMO-specific protease SENP5
    NP_001344016.1
    NP_001344017.1
    NP_796077.2
    XP_006522303.1
    XP_006522305.1
    XP_036015874.1
    XP_036015875.1
    XP_036015876.1
    XP_036015877.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357087.1 → NP_001344016.1  sentrin-specific protease 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124681
      Consensus CDS
      CCDS28111.1
      UniProtKB/Swiss-Prot
      Q3ZTK4, Q6NXL6, Q8BXW0
      UniProtKB/TrEMBL
      F6S6C3
      Related
      ENSMUSP00000023457.6, ENSMUST00000023457.13
      Conserved Domains (2) summary
      pfam02902
      Location:575 → 747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:488 → 545
      DEK_C; DEK C terminal domain

    2. NM_001357088.1 → NP_001344017.1  sentrin-specific protease 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124681
      UniProtKB/TrEMBL
      F6S6C3
      Related
      ENSMUSP00000115257.2, ENSMUST00000129900.2
      Conserved Domains (2) summary
      COG5160
      Location:567 → 620
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
      pfam08766
      Location:488 → 545
      DEK_C; DEK C terminal domain

    3. NM_177103.4 → NP_796077.2  sentrin-specific protease 5 isoform 1

      See identical proteins and their annotated locations for NP_796077.2

      Status: VALIDATED

      Source sequence(s)
      AC124681, AK028177, BC067014, BG146216
      Consensus CDS
      CCDS28111.1
      UniProtKB/Swiss-Prot
      Q3ZTK4, Q6NXL6, Q8BXW0
      UniProtKB/TrEMBL
      F6S6C3
      Related
      ENSMUSP00000156109.2, ENSMUST00000231360.2
      Conserved Domains (2) summary
      pfam02902
      Location:575 → 747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:488 → 545
      DEK_C; DEK C terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      31778488..31829388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159982.1 → XP_036015875.1  sentrin-specific protease 5 isoform X1

      UniProtKB/Swiss-Prot
      Q3ZTK4, Q6NXL6, Q8BXW0
      UniProtKB/TrEMBL
      F6S6C3
      Conserved Domains (2) summary
      pfam02902
      Location:575 → 747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:488 → 545
      DEK_C; DEK C terminal domain

    2. XM_036159981.1 → XP_036015874.1  sentrin-specific protease 5 isoform X1

      UniProtKB/Swiss-Prot
      Q3ZTK4, Q6NXL6, Q8BXW0
      UniProtKB/TrEMBL
      F6S6C3
      Conserved Domains (2) summary
      pfam02902
      Location:575 → 747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:488 → 545
      DEK_C; DEK C terminal domain

    3. XM_006522242.5 → XP_006522305.1  sentrin-specific protease 5 isoform X3

      UniProtKB/TrEMBL
      F6S6C3
      Conserved Domains (1) summary
      COG5160
      Location:567 → 702
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    4. XM_036159983.1 → XP_036015876.1  sentrin-specific protease 5 isoform X1

      UniProtKB/Swiss-Prot
      Q3ZTK4, Q6NXL6, Q8BXW0
      UniProtKB/TrEMBL
      F6S6C3
      Conserved Domains (2) summary
      pfam02902
      Location:575 → 747
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
      pfam08766
      Location:488 → 545
      DEK_C; DEK C terminal domain

    5. XM_036159984.1 → XP_036015877.1  sentrin-specific protease 5 isoform X4

      Conserved Domains (1) summary
      COG5160
      Location:6 → 187
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    6. XM_006522240.5 → XP_006522303.1  sentrin-specific protease 5 isoform X2

      Conserved Domains (1) summary
      cl23802
      Location:591 → 721
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RNA

    1. XR_004939195.1 RNA Sequence

    2. XR_003951796.2 RNA Sequence

    3. XR_004939194.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_023801.1: Suppressed sequence

      Description
      NM_023801.1: This RefSeq was permanently suppressed because it is entirely UTR sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NXL6.1 GenPept UniProtKB/Swiss-Prot:Q6NXL6

    Gene LinkOut

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