Notum notum palmitoleoyl-protein carboxylesterase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Notumprovided by MGI
Official Full Name: notum palmitoleoyl-protein carboxylesteraseprovided by MGI
Primary source: MGI:MGI:1924833
See related: Ensembl:ENSMUSG00000042988 AllianceGenome:MGI:1924833
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730593N15Rik
Summary: Enables lipase activity and palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development; negative regulation of canonical Wnt signaling pathway; and regulation of bone mineralization. Predicted to be located in extracellular region. Is expressed in several structures, including genitourinary system; heart valve; respiratory system; sensory organ; and vibrissa. Orthologous to human NOTUM (notum, palmitoleoyl-protein carboxylesterase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 11.4), kidney adult (RPKM 4.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 84.38 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120544614..120552019, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120653788..120661193, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Notum deacylates octanoylated ghrelin.
Title: Notum deacylates octanoylated ghrelin.
Notum Deletion From Late-Stage Skeletal Cells Increases Cortical Bone Formation and Potentiates Skeletal Effects of Sclerostin Inhibition.
Title: Notum Deletion From Late-Stage Skeletal Cells Increases Cortical Bone Formation and Potentiates Skeletal Effects of Sclerostin Inhibition.
NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice.
Title: NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice.
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Title: NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Osteocyte- and late osteoblast-derived NOTUM reduces cortical bone mass in mice.
Title: Osteocyte- and late osteoblast-derived NOTUM reduces cortical bone mass in mice.
Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator.
Title: Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator.
Therapies targeting osteoblast-derived NOTUM may prevent nonvertebral fractures.
Title: Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans.
results reveal a role of the stem cell niche in ageing and demonstrate that targeting of Notum can promote regeneration of aged tissues
Title: Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.
Notum influences mesenchymal cell differentiation by generating a barrier for Wnt ligands produced and secreted by airway epithelial cells to attenuate Wnt signaling.
Title: Notum attenuates Wnt/β-catenin signaling to promote tracheal cartilage patterning.
The findings support a significant role for NOTUM in modulating WNT signaling pathways that have pleiotropic effects on tooth and kidney development.
Title: Dentin Dysplasia in Notum Knockout Mice.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (1)
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoleyl hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoleyl hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoleyl hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT involved_in GPI anchor release	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein depalmitoleylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein depalmitoleylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein depalmitoleylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of bone mineralization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of bone mineralization	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: palmitoleoyl-protein carboxylesterase NOTUM

Names: notum pectinacetylesterase homolog; protein notum homolog

NP_001369198.1

EC 3.1.1.98

NP_001369199.1

EC 3.1.1.98

NP_001402705.1

EC 3.1.1.98

NP_780472.3

EC 3.1.1.98

XP_006534560.1

EC 3.1.1.98

XP_011247617.1

EC 3.1.1.98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001382269.1 → NP_001369198.1 palmitoleoyl-protein carboxylesterase NOTUM isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL663030

UniProtKB/Swiss-Prot

A2ABZ5, A2ABZ6, Q8R116

Conserved Domains (1) summary

pfam03283
Location:88 → 426

PAE; Pectinacetylesterase
NM_001382270.1 → NP_001369199.1 palmitoleoyl-protein carboxylesterase NOTUM isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL663030

Conserved Domains (1) summary

pfam03283
Location:88 → 242

PAE; Pectinacetylesterase
NM_001415776.1 → NP_001402705.1 palmitoleoyl-protein carboxylesterase NOTUM isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL663030

UniProtKB/Swiss-Prot

A2ABZ5, A2ABZ6, Q8R116

Related

ENSMUSP00000101783.2, ENSMUST00000106177.8
NM_175263.4 → NP_780472.3 palmitoleoyl-protein carboxylesterase NOTUM isoform 1 precursor

See identical proteins and their annotated locations for NP_780472.3

Status: VALIDATED

Source sequence(s)

AI849590, AK019987, AL663030, DN174397

Consensus CDS

CCDS49007.1

UniProtKB/Swiss-Prot

A2ABZ5, A2ABZ6, Q8R116

Related

ENSMUSP00000101784.3, ENSMUST00000106178.9

Conserved Domains (1) summary

pfam03283
Location:88 → 426

PAE; Pectinacetylesterase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

120544614..120552019 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534497.4 → XP_006534560.1 palmitoleoyl-protein carboxylesterase NOTUM isoform X2

Conserved Domains (1) summary

pfam03283
Location:123 → 277

PAE; Pectinacetylesterase
XM_011249315.1 → XP_011247617.1 palmitoleoyl-protein carboxylesterase NOTUM isoform X1

Conserved Domains (1) summary

pfam03283
Location:114 → 424

PAE; Pectinacetylesterase