Diablo diablo, IAP-binding mitochondrial protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Diabloprovided by RGD
Official Full Name: diablo, IAP-binding mitochondrial proteinprovided by RGD
Primary source: RGD:1310885
See related: Ensembl:ENSRNOG00000029197 AllianceGenome:RGD:1310885
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Smac
Summary: Predicted to be involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; intrinsic apoptotic signaling pathway in response to oxidative stress; and neuron apoptotic process. Predicted to act upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process. Located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 64. Orthologous to human DIABLO (diablo IAP-binding mitochondrial protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 781.3), Kidney (RPKM 174.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (38716668..38731285)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (33055784..33070401)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (38490230..38503344)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of Different Degrees of Carotid Artery Stenosis on the Expression of XIAP and Smac in the Ischemic Penumbra of Rats with Cerebral Ischemia-Reperfusion.
Title: Effects of Different Degrees of Carotid Artery Stenosis on the Expression of XIAP and Smac in the Ischemic Penumbra of Rats with Cerebral Ischemia-Reperfusion.
Omi/HtrA2, but not Smac/DIABLO, expression was increased in aging hearts.
Title: Variations in the protein level of Omi/HtrA2 in the heart of aged rats may contribute to the increased susceptibility of cardiomyocytes to ischemia/reperfusion injury and cell death : Omi/HtrA2 and aged heart injury.
Prolonged hypothermic preservation of myocardium might lead to the expression of Smac/DIABLO protein and induce cardiomyocyte apoptosis.
Title: [Dynamic changes of Smac/DIABLO protein expression in rat donor myocardium suffered from hypothermic preservation].
Mitochondria signal channel plays an important role in the endotoxin-induced apoptosis of hepatic cells by promoting the release of smac from mitochondria to cytoplasm and activating caspase-9 and caspase-3.
Title: Effects of endotoxin on liver Smac apoptosis channel.
data reveal that Smac/DIABLO is a target of ARC in counteracting apoptosis
Title: Mitochondrial fission leads to Smac/DIABLO release quenched by ARC.
Results describe the role of IAP and Smac/DIABLO in neuronal death.
Title: Role of inhibitor of apoptosis proteins and Smac/DIABLO in staurosporine-induced cerebellar granule neurons death.
Balance and location of anti-apoptotic proteins vs. pro-apoptotic proteins may be associated with the translocation of Smac/DIABLO from the mitochondria to the cytosol and therefore closely related to cell death or survival after focal cerebral ischemia.
Title: Dynamic changes of the anti- and pro-apoptotic proteins Bcl-w, Bcl-2, and Bax with Smac/Diablo mitochondrial release after photothrombotic ring stroke in rats.
Smac/DIABLO expression was associated with alteration of the XIAP levels
Title: Regulation of XIAP and Smac/DIABLO in the rat hippocampus following transient forebrain ischemia.
The mechanism of Abeta-induced neuronal apoptosis sequentially involves JNK activation, Bcl-w downregulation, and release of mitochondrial Smac, followed by cell death.
Title: Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w.
Smac/DIABLO was elevated at diestrus, proestrus and metestrus but was minimal at estrus. Smac/DIABLO and XIAP are regulated differently and may play important roles in the regulation of endometrial cell fate.
Title: Opposite regulation of XIAP and Smac/DIABLO in the rat endometrium in response to 17beta-estradiol at estrus.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Diablo (e-PCR), detects polymorphism
- UniSTS:507426

BF397544 (e-PCR)
- UniSTS:246222

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CD40 receptor complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: diablo IAP-binding mitochondrial protein

Names: diablo homolog, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.