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    Ldaf1 lipid droplet assembly factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 378467, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ldaf1provided by RGD
    Official Full Name
    lipid droplet assembly factor 1provided by RGD
    Primary source
    RGD:727895
    See related
    Ensembl:ENSRNOG00000048250 AllianceGenome:RGD:727895
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem159
    Summary
    Predicted to be involved in lipid droplet formation. Predicted to be located in endoplasmic reticulum membrane and lipid droplet. Orthologous to human LDAF1 (lipid droplet assembly factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 268.8), Heart (RPKM 202.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ldaf1 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (183915919..183934374)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (174484438..174503037)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (189870596..189889485)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 3 Neighboring gene uncharacterized LOC120099919 Neighboring gene replication protein A3, pseudogene 1 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 4B Neighboring gene zona pellucida glycoprotein 2 Neighboring gene crystallin, mu

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LDAF1 and Seipin Form a Lipid Droplet Assembly Complex. Chung J, et al. Dev Cell, 2019 Dec 2. PMID 31708432, Free PMC Article
    2. Promethin Is a Conserved Seipin Partner Protein. Castro IG, et al. Cells, 2019 Mar 21. PMID 30901948, Free PMC Article
    3. Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver. Yu S, et al. Biochimie, 2004 Nov. PMID 15589683
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in lipid droplet formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid droplet formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lipid droplet assembly factor 1
    Names
    promethin
    transmembrane protein 159

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194354.2 → NP_919335.2  lipid droplet assembly factor 1

      See identical proteins and their annotated locations for NP_919335.2

      Status: PROVISIONAL

      Source sequence(s)
      BC076384
      UniProtKB/Swiss-Prot
      Q6DGG2, Q6UK00
      UniProtKB/TrEMBL
      A0A8I6A4Z9, A6I8P8
      Related
      ENSRNOP00000086075.1, ENSRNOT00000100388.1
      Conserved Domains (1) summary
      pfam16015
      Location:41 → 128
      Promethin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      183915919..183934374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085906.2 → XP_038941834.1  lipid droplet assembly factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6DGG2, Q6UK00
      UniProtKB/TrEMBL
      A0A0G2JSZ8
      Conserved Domains (1) summary
      pfam16015
      Location:41 → 134
      Promethin

    2. XM_039085913.2 → XP_038941841.1  lipid droplet assembly factor 1 isoform X2

      UniProtKB/Swiss-Prot
      Q6DGG2, Q6UK00
      Conserved Domains (1) summary
      pfam16015
      Location:41 → 134
      Promethin

    3. XM_039085922.2 → XP_038941850.1  lipid droplet assembly factor 1 isoform X3

      UniProtKB/Swiss-Prot
      Q6DGG2, Q6UK00
      Conserved Domains (1) summary
      pfam16015
      Location:41 → 128
      Promethin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UK00.1 GenPept UniProtKB/Swiss-Prot:Q6UK00

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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