Stimate STIM activating enhancer [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stimateprovided by RGD
Official Full Name: STIM activating enhancerprovided by RGD
Primary source: RGD:735152
See related: Ensembl:ENSRNOG00000017051 AllianceGenome:RGD:735152
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmem110
Summary: Predicted to enable calcium channel regulator activity. Predicted to be involved in activation of store-operated calcium channel activity; calcium-mediated signaling using intracellular calcium source; and positive regulation of calcineurin-NFAT signaling cascade. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in cortical endoplasmic reticulum and membrane. Orthologous to several human genes including STIMATE (STIM activating enhancer). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 82.5), Thymus (RPKM 77.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p16

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (6019788..6077272)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (6013392..6070829)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (6903212..6958786)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in activation of store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in positive regulation of calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcineurin-NFAT signaling cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in store-operated calcium entry	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cortical endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in cortical endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum-plasma membrane contact site	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum-plasma membrane contact site	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: store-operated calcium entry regulator STIMATE

Names: STIM-activating enhancer encoded by TMEM110; transmembrane protein 110

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198774.2 → NP_942069.1 store-operated calcium entry regulator STIMATE

See identical proteins and their annotated locations for NP_942069.1

Status: PROVISIONAL

Source sequence(s)

BC088092

UniProtKB/Swiss-Prot

Q7TSW6

UniProtKB/TrEMBL

A0A8I5ZKL5, A6KG24

Related

ENSRNOP00000023314.4, ENSRNOT00000023314.5

Conserved Domains (1) summary

pfam12400
Location:100 → 219

STIMATE; STIMATE family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

6019788..6077272

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275492.1 → XP_063131562.1 store-operated calcium entry regulator STIMATE isoform X2
XM_039094618.2 → XP_038950546.1 store-operated calcium entry regulator STIMATE isoform X1

Conserved Domains (1) summary

pfam12400
Location:20 → 139

STIMATE; STIMATE family
XM_063275491.1 → XP_063131561.1 store-operated calcium entry regulator STIMATE isoform X1
XM_063275490.1 → XP_063131560.1 store-operated calcium entry regulator STIMATE isoform X1