Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gbf1provided by RGD
Official Full Name: golgi brefeldin A resistant guanine nucleotide exchange factor 1provided by RGD
Primary source: RGD:1307160
See related: Ensembl:ENSRNOG00000026048 AllianceGenome:RGD:1307160
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307160
Summary: Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,5-bisphosphate binding activity. Predicted to be involved in several processes, including Golgi disassembly; Golgi vesicle transport; and protein localization to organelle. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum lumen; and peroxisome. Orthologous to human GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 169.8), Heart (RPKM 139.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (254959784..255088479)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (245018535..245147052)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (265904616..266033107)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AW049900 (e-PCR)
- UniSTS:181254

BF406297 (e-PCR)
- UniSTS:248328

BE103146 (e-PCR)
- UniSTS:244748

RH138408 (e-PCR)
- UniSTS:220495

BE108790 (e-PCR)
- UniSTS:247889

RH128849 (e-PCR)
- UniSTS:212157

RH143137 (e-PCR)
- UniSTS:232384

RH137769 (e-PCR)
- UniSTS:219856

AI035702 (e-PCR)
- UniSTS:181247

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in COPI coating of Golgi vesicle	ISO Inferred from Sequence Orthology more info
involved_in Golgi disassembly	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi to endosome transport	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum-Golgi intermediate compartment organization	ISO Inferred from Sequence Orthology more info
involved_in establishment of monopolar cell polarity	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
involved_in protein localization to endoplasmic reticulum tubular network	ISO Inferred from Sequence Orthology more info
involved_in reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi stack	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

Names: golgi-specific brefeldin A resistant guanine nucleotide exchange factor 1; golgi-specific brefeldin A-resistance factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191634.1 → NP_001178563.1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6JHL5

Conserved Domains (3) summary

COG5307
Location:483 → 1162

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

pfam01369
Location:699 → 884

Sec7; Sec7 domain

pfam12783
Location:400 → 545

Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

254959784..255088479

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231500.5 → XP_006231562.1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X8

UniProtKB/TrEMBL

A6JHL5

Conserved Domains (3) summary

COG5307
Location:484 → 1163

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

pfam01369
Location:700 → 885

Sec7; Sec7 domain

pfam12783
Location:401 → 546

Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
XM_006231501.5 → XP_006231563.1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X9

UniProtKB/TrEMBL

A6JHL5, F1M8X9

Related

ENSRNOP00000038037.6

Conserved Domains (3) summary

COG5307
Location:484 → 1163

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

pfam01369
Location:700 → 885

Sec7; Sec7 domain

pfam12783
Location:401 → 546

Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
XM_006231502.5 → XP_006231564.1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X10

UniProtKB/TrEMBL

A6JHL5

Conserved Domains (3) summary

COG5307
Location:483 → 1162

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

pfam01369
Location:699 → 884

Sec7; Sec7 domain

pfam12783
Location:400 → 545

Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
XM_039080486.2 → XP_038936414.1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X5

UniProtKB/TrEMBL

A6JHL5

Conserved Domains (4) summary

PHA03247
Location:1756 → 1886

PHA03247; large tegument protein UL36; Provisional

COG5307
Location:510 → 1029

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

pfam01369
Location:726 → 911

Sec7; Sec7 domain

pfam12783
Location:427 → 572

Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
XM_006231496.5 → XP_006231558.1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1

UniProtKB/TrEMBL

A6JHL5

Conserved Domains (2) summary

pfam01369
Location:733 → 918

Sec7; Sec7 domain

pfam12783
Location:434 → 579

Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
XM_006231497.5 → XP_006231559.1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X2

UniProtKB/TrEMBL

A6JHL5

Conserved Domains (2) summary

pfam01369
Location:732 → 917

Sec7; Sec7 domain

pfam12783
Location:433 → 578

Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
XM_039080492.2 → XP_038936420.1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X6

UniProtKB/TrEMBL

A6JHL5

Conserved Domains (4) summary

PHA03247
Location:1755 → 1885

PHA03247; large tegument protein UL36; Provisional

COG5307
Location:509 → 1028

COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]

pfam01369
Location:725 → 910

Sec7; Sec7 domain

pfam12783
Location:426 → 571

Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
XM_063264977.1 → XP_063121047.1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X11

UniProtKB/TrEMBL

A6JHL5
XM_063264979.1 → XP_063121049.1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X12

UniProtKB/TrEMBL

A6JHL5
XM_006231498.5 → XP_006231560.1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X3

UniProtKB/TrEMBL

A6JHL5

Conserved Domains (2) summary

pfam01369
Location:733 → 918

Sec7; Sec7 domain

pfam12783
Location:434 → 579

Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
XM_063264948.1 → XP_063121018.1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X4

UniProtKB/TrEMBL

A6JHL5
XM_063264959.1 → XP_063121029.1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X7

UniProtKB/TrEMBL

A6JHL5