Slc27a4 solute carrier family 27 (fatty acid transporter), member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc27a4provided by MGI
Official Full Name: solute carrier family 27 (fatty acid transporter), member 4provided by MGI
Primary source: MGI:MGI:1347347
See related: Ensembl:ENSMUSG00000059316 AllianceGenome:MGI:1347347
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FATP4; ACSVL4
Summary: Enables oleoyl-CoA ligase activity and very long-chain fatty acid-CoA ligase activity. Involved in glucose import in response to insulin stimulus; long-chain fatty acid import into cell; and negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. Acts upstream of or within fatty acid metabolic process; lipid transport; and skin development. Located in brush border membrane; endoplasmic reticulum; and microvillus. Is expressed in several structures, including alimentary system; eye; liver; nervous system; and urinary system. Used to study lethal restrictive dermopathy. Orthologous to human SLC27A4 (solute carrier family 27 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 297.3), small intestine adult (RPKM 226.2) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 20.64 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (29692646..29707534)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (29802634..29817522)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myeloid-specific fatty acid transport protein 4 deficiency induces a sex-dimorphic susceptibility for nonalcoholic steatohepatitis in mice fed a high-fat, high-cholesterol diet.
Title: Myeloid-specific fatty acid transport protein 4 deficiency induces a sex-dimorphic susceptibility for nonalcoholic steatohepatitis in mice fed a high-fat, high-cholesterol diet.
PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport.
Title: PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport.
Inverse correlation between fatty acid transport protein 4 and vision in Leber congenital amaurosis associated with RPE65 mutation.
Title: Inverse correlation between fatty acid transport protein 4 and vision in Leber congenital amaurosis associated with RPE65 mutation.
The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Fatty Acids Into Skeletal Muscle via Fatty Acid Transporter SLC27A4/FATP4.
Title: The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Fatty Acids Into Skeletal Muscle via Fatty Acid Transporter SLC27A4/FATP4.
Fatp4 knockout (KO) mice exhibited severe skin barrier dysfunction and morphological abnormalities in the epidermis and the total amount of acylceramide was reduced to approximately 10% of wild-type mice.
Title: Skin permeability barrier formation by the ichthyosis-causative gene FATP4 through formation of the barrier lipid ω-O-acylceramide.
hepatic FATP4 deletion rendered an increase of blood lipids including glycerol indicating a preferential fatty-acid channeling to triglyceride pools that are specifically available for lipolysis
Title: Elevation of blood lipids in hepatocyte-specific fatty acid transport 4-deficient mice fed with high glucose diets.
The mRNA levels of FATP4 in the placenta in the high-fat diet group were significantly upregulated compared to the control diet group.
Title: Sex-specific Alterations in Serology and the Expression of Liver FATP4 Protein in Offspring Exposed to High-Fat Diet during Pregnancy and/or Lactation.
Transgenic expression of FATP1 in suprabasal keratinocytes rescued the phenotype of Fatp4 mutants, and FATP1 sorted to the same intracellular organelles as endogenous FATP4
Title: Fatty acid transport protein 1 can compensate for fatty acid transport protein 4 in the developing mouse epidermis.
a spontaneous Fatp4/Scl27a4 splice site mutation in congenital ichthyosis
Title: A spontaneous Fatp4/Scl27a4 splice site mutation in a new murine model for congenital ichthyosis.
FATP4 plays crucial roles in the development and maturation of both sebaceous and meibomian glands, as well as in the formation and composition of sebum
Title: Requirement of fatty acid transport protein 4 for development, maturation, and function of sebaceous glands in a mouse model of ichthyosis prematurity syndrome.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (1)
Spontaneous (2) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB144259 (e-PCR)
- UniSTS:185468

Slc27a4 (e-PCR), detects polymorphism
- UniSTS:527546

MARC_31864-31866:1046726005:1 (e-PCR)
- UniSTS:471495

SLC27A4_834 (e-PCR)
- UniSTS:277742

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid-CoA ligase activity	TAS Traceable Author Statement more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oleoyl-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oleoyl-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables oleoyl-CoA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oleoyl-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables palmitoyl-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables very long-chain fatty acid-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables very long-chain fatty acid-CoA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within activation of GTPase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in glucose import in response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipid transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid import into cell	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid import into cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid import into cell	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-chain fatty acid metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within long-chain fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in medium-chain fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within medium-chain fatty acid transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within medium-chain fatty acid transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within very long-chain fatty acid catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within very long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within very long-chain fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: long-chain fatty acid transport protein 4

Names: arachidonate--CoA ligase; long-chain-fatty-acid--CoA ligase; very long-chain acyl-CoA synthetase 4

NP_036119.1

EC 6.2.1.15

EC 6.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011989.5 → NP_036119.1 long-chain fatty acid transport protein 4

See identical proteins and their annotated locations for NP_036119.1

Status: VALIDATED

Source sequence(s)

AL845323, BX294378

Consensus CDS

CCDS15858.1

UniProtKB/Swiss-Prot

O88562, Q3TD48, Q91VE0

Related

ENSMUSP00000078971.3, ENSMUST00000080065.3

Conserved Domains (2) summary

cd05939
Location:99 → 608

hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins

PRK08279
Location:75 → 643

PRK08279; long-chain-acyl-CoA synthetase; Validated