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    Bicra BRD4 interacting chromatin remodeling complex associated protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292622, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Bicraprovided by RGD
    Official Full Name
    BRD4 interacting chromatin remodeling complex associated proteinprovided by RGD
    Primary source
    RGD:1306385
    See related
    Ensembl:ENSRNOG00000011262 AllianceGenome:RGD:1306385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gltscr1
    Summary
    Predicted to enable transcription regulator activator activity. Predicted to be involved in positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of SWI/SNF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome. Orthologous to human BICRA (BRD4 interacting chromatin remodeling complex associated protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 31.9), Thymus (RPKM 22.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bicra in Genome Data Viewer
    Location:
    1q21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (85790093..85867656, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (76661897..76736146, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (77869020..77943828, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 23 Neighboring gene NOP53 ribosome biogenesis factor Neighboring gene EH-domain containing 2 Neighboring gene uncharacterized LOC103691043 Neighboring gene zinc finger protein 541 Neighboring gene NSF attachment protein alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. Alpsoy A, et al. J Biol Chem, 2018 Mar 16. PMID 29374058, Free PMC Article
    2. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Rahman S, et al. Mol Cell Biol, 2011 Jul. PMID 21555454, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription regulator activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SWI/SNF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BRD4-interacting chromatin-remodeling complex-associated protein
    Names
    BRD4 interacting chromatin remodelling complex associated protein
    glioma tumor suppressor candidate region gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106226.2 → NP_001099696.2  BRD4-interacting chromatin-remodeling complex-associated protein

      See identical proteins and their annotated locations for NP_001099696.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6J889, D3ZQW8
      Conserved Domains (1) summary
      pfam15249
      Location:1096 → 1200
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      85790093..85867656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228344.5 → XP_006228406.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4I1, A6J889
      Related
      ENSRNOP00000086008.1
      Conserved Domains (1) summary
      pfam15249
      Location:1074 → 1178
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    2. XM_006228345.5 → XP_006228407.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZXV5, A6J889
      Related
      ENSRNOP00000084339.1
      Conserved Domains (1) summary
      pfam15249
      Location:1037 → 1141
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    3. XM_006228343.5 → XP_006228405.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006228405.1

      UniProtKB/TrEMBL
      A6J889, D3ZQW8
      Related
      ENSRNOP00000015059.5
      Conserved Domains (1) summary
      pfam15249
      Location:1096 → 1200
      GLTSCR1; Conserved region of unknown function on GLTSCR protein
    Nucleotide Protein Strain
    Heading Accession and Version

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