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    Fgfr1op2 FGFR1 oncogene partner 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362463, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Fgfr1op2provided by RGD
    Official Full Name
    FGFR1 oncogene partner 2provided by RGD
    Primary source
    RGD:1303233
    See related
    Ensembl:ENSRNOG00000001811 AllianceGenome:RGD:1303233
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wit3.0
    Summary
    Predicted to enable identical protein binding activity. Involved in response to wounding. Located in cytoplasm. Orthologous to human FGFR1OP2 (FGFR1 oncogene partner 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 226.1), Heart (RPKM 196.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fgfr1op2 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (181222298..181243318)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (179491602..179512630)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (180887182..180908206)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486659 Neighboring gene integrator complex subunit 13 Neighboring gene E3 SUMO-protein ligase NSE2-like Neighboring gene transmembrane 7 superfamily member 3 Neighboring gene mediator complex subunit 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Oral fibroblast expression of wound-inducible transcript 3.0 (wit3.0) accelerates the collagen gel contraction in vitro. Sukotjo C, et al. J Biol Chem, 2003 Dec 19. PMID 14527947
    2. Molecular cloning of wound inducible transcript (wit 3.0) differentially expressed in edentulous oral mucosa undergoing tooth extraction wound-healing. Sukotjo C, et al. J Dent Res, 2002 Apr. PMID 12097305
    3. Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure. Lin A, et al. Am J Pathol, 2010 Jan. PMID 19959814, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FGFR1OP2/wit3.0 may regulate cell motility and stimulate wound closure.
      Title: Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure.
    2. expressed by the fibroblasts associated with tooth extraction wound-healing (wit 3.0)
      Title: Molecular cloning of wound inducible transcript (wit 3.0) differentially expressed in edentulous oral mucosa undergoing tooth extraction wound-healing.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to wounding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FGFR1 oncogene partner 2 homolog
    Names
    Wit3.0_alpha
    Wit3.0_beta
    wound inducible transcript 3.0 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201421.2 → NP_958824.2  FGFR1 oncogene partner 2 homolog

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q5PPH1, Q6TA25, Q6TA26
      UniProtKB/TrEMBL
      A0A8L2QKW1, A6IN22
      Related
      ENSRNOP00000039568.3, ENSRNOT00000042270.4
      Conserved Domains (1) summary
      pfam05769
      Location:2 → 221
      SIKE; SIKE family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      181222298..181243318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237688.4 → XP_006237750.1  FGFR1 oncogene partner 2 homolog isoform X1

      See identical proteins and their annotated locations for XP_006237750.1

      UniProtKB/TrEMBL
      A0A8L2QKW1, A6IN23
      Related
      ENSRNOP00000002476.2
      Conserved Domains (1) summary
      pfam05769
      Location:2 → 183
      SIKE; SIKE family

    2. XM_008763402.3 → XP_008761624.1  FGFR1 oncogene partner 2 homolog isoform X2

      See identical proteins and their annotated locations for XP_008761624.1

      UniProtKB/TrEMBL
      A6IN24
      Conserved Domains (1) summary
      pfam05769
      Location:2 → 133
      DUF837; Protein of unknown function (DUF837)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TA25.2 GenPept UniProtKB/Swiss-Prot:Q6TA25

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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