Got1 glutamic-oxaloacetic transaminase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Got1provided by RGD
Official Full Name: glutamic-oxaloacetic transaminase 1provided by RGD
Primary source: RGD:2721
See related: Ensembl:ENSRNOG00000016356 AllianceGenome:RGD:2721
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AAT1; ASAT; cCAT; Aspat; Gaspat; cAspAT
Summary: Enables L-aspartate:2-oxoglutarate aminotransferase activity; L-cysteine:2-oxoglutarate aminotransferase activity; and carboxylic acid binding activity. Involved in several processes, including cellular response to mechanical stimulus; dicarboxylic acid metabolic process; and ion homeostasis. Located in axon terminus; cytosol; and lysosome. Used to study transient cerebral ischemia. Biomarker of cardiomyopathy. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 923.3), Muscle (RPKM 643.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (252306541..252337622, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (242357293..242381535, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (263246248..263269762, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis.
Title: Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis.
Hydrogen sulfide (H2 S) is synthesized in peripheral neurons through two mitochondrial enzymes, mercaptopyruvate sulfurtransferase (MPST)and cysteine aminotransferase (CAT).
Title: Contribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neurons.
In vivo lentiviral gene delivery of GOT minimized lesion volume, whereas GOT knockdown worsened stroke outcomes. Thus, brain tissue GOT emerges as a novel target in managing stroke outcomes.
Title: Oxygen-inducible glutamate oxaloacetate transaminase as protective switch transforming neurotoxic glutamate to metabolic fuel during acute ischemic stroke.
Results suggest that downregulation of the endogenous SO(2)/GOT pathway is likely involved in the pathogenesis of ISO-induced myocardial injury.
Title: Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132794 (e-PCR)
- UniSTS:216077

Got1 (e-PCR), detects polymorphism
- UniSTS:506944

GOT1 (e-PCR)
- UniSTS:266597

d1mgh12 (e-PCR)
- UniSTS:121448

RH128564 (e-PCR)
- UniSTS:211872

RH94745 (e-PCR)
- UniSTS:119992

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-aspartate:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-aspartate:2-oxoglutarate aminotransferase activity	ISO Inferred from Sequence Orthology more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-cysteine transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables carboxylic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in aspartate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in aspartate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within aspartate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in aspartate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in aspartate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in aspartate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in aspartate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in dicarboxylic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dicarboxylic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in glutamate catabolic process to 2-oxoglutarate	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamate catabolic process to 2-oxoglutarate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glutamate catabolic process to 2-oxoglutarate	ISO Inferred from Sequence Orthology more info
involved_in glutamate catabolic process to aspartate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glutamate catabolic process to aspartate	ISO Inferred from Sequence Orthology more info
involved_in glutamate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycerol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oxaloacetate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in oxaloacetate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oxaloacetate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to carbohydrate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	ISO Inferred from Sequence Orthology more info
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to transition metal nanoparticle	IDA Inferred from Direct Assay more info	PubMed
involved_in transdifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aspartate aminotransferase, cytoplasmic

Names: aspartate aminotransferase 1; cysteine aminotransferase, cytoplasmic; cysteine transaminase, cytoplasmic; cytosolic aspartate aminotransferase; glutamate oxaloacetate transaminase 1, soluble; glutamic-oxaloacetic transaminase 1, soluble; transaminase A

NP_036703.2

EC 2.6.1.1

EC 2.6.1.3

XP_063136708.1

EC 2.6.1.1

EC 2.6.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.