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    Tbxas1 thromboxane A synthase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24886, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Tbxas1provided by RGD
    Official Full Name
    thromboxane A synthase 1provided by RGD
    Primary source
    RGD:3826
    See related
    Ensembl:ENSRNOG00000007918 AllianceGenome:RGD:3826
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable heme binding activity; hydroperoxy icosatetraenoate dehydratase activity; and thromboxane-A synthase activity. Involved in several processes, including cellular chloride ion homeostasis; positive regulation of vasoconstriction; and response to ethanol. Predicted to be located in endoplasmic reticulum membrane. Used to study acute necrotizing pancreatitis; artery disease (multiple); brain infarction; glomerulonephritis (multiple); and thrombosis. Biomarker of hydronephrosis. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome; cerebral infarction; and platelet-type bleeding disorder 14. Orthologous to human TBXAS1 (thromboxane A synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 48.4), Lung (RPKM 37.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbxas1 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (68631841..68803959)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (67664963..67837096)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (66624181..66846745)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 2, member L Neighboring gene homeodomain interacting protein kinase 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene poly (ADP-ribose) polymerase family, member 12 Neighboring gene uncharacterized LOC134486573 Neighboring gene lysine demethylase 7A Neighboring gene RNA, U6 small nuclear 604

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Downregulation of TBXAS1 in an iron-induced malignant mesothelioma model. Minami D, et al. Cancer Sci, 2015 Oct. PMID 26211743, Free PMC Article
    2. A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension. Kataoka M, et al. Am J Respir Crit Care Med, 2005 Dec 15. PMID 16192456
    3. Protective effect of FK506 and thromboxane synthase inhibitor on ischemia-reperfusion injury in non-heart-beating donor in rat orthotopic liver transplantation. Sasaki K, et al. J Med Invest, 2004 Feb. PMID 15000260
    4. Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger. Imamura T, et al. Arzneimittelforschung, 2003. PMID 14650360
    5. Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat. Jones AE, et al. Am J Physiol Lung Cell Mol Physiol, 2003 Jun. PMID 12639842

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TBXAS1 gene expression was downregulated in rats with iron-induced mesothelioma.
      Title: Downregulation of TBXAS1 in an iron-induced malignant mesothelioma model.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 12-hydroxyheptadecatrienoic acid synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydroperoxy icosatetraenoate dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydroperoxy icosatetraenoate dehydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thromboxane-A synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thromboxane-A synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in icosanoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in icosanoid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular chloride ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    thromboxane-A synthase
    Names
    TXA synthase
    TXS
    ThromboxA ane synthase 1
    cytochrome P450 5A1
    hydroperoxy icosatetraenoate dehydratase
    thromboxane A synthase 1, platelet
    NP_036819.1
    XP_038963001.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012687.2 → NP_036819.1  thromboxane-A synthase

      See identical proteins and their annotated locations for NP_036819.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P49430
      UniProtKB/TrEMBL
      A6IET4
      Related
      ENSRNOP00000010796.2, ENSRNOT00000010796.5
      Conserved Domains (1) summary
      pfam00067
      Location:47 → 530
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      68631841..68803959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107073.2 → XP_038963001.1  thromboxane-A synthase isoform X1

      Conserved Domains (1) summary
      cl41757
      Location:74 → 379
      cytochrome_P450; cytochrome P450 (CYP) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49430.1 GenPept UniProtKB/Swiss-Prot:P49430

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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