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    Vwa7 von Willebrand factor A domain containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 27762, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Vwa7provided by MGI
    Official Full Name
    von Willebrand factor A domain containing 7provided by MGI
    Primary source
    MGI:MGI:1306798
    See related
    Ensembl:ENSMUSG00000007030 AllianceGenome:MGI:1306798
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G7c; NG37; C6orf27; D17H6S56E-3
    Summary
    Predicted to be located in extracellular region. Orthologous to human VWA7 (von Willebrand factor A domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 7.5), heart adult (RPKM 3.0) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vwa7 in Genome Data Viewer
    Location:
    17 B1; 17 18.55 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35235388..35245717)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35016360..35026741)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 17, human D6S56E 5 Neighboring gene STARR-positive B cell enhancer ABC_E1941 Neighboring gene STARR-positive B cell enhancer ABC_E7526 Neighboring gene valyl-tRNA synthetase 1 Neighboring gene suppressor APC domain containing 1 Neighboring gene predicted gene, 52318 Neighboring gene mutS homolog 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:35183800-35183983 Neighboring gene STARR-positive B cell enhancer ABC_E8671 Neighboring gene predicted gene, 23421

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel locus affecting serum levels of IgG2a maps to the murine H2 region. Matthews VB, et al. Eur J Immunogenet, 2000 Jun. PMID 10940081
    2. G7c, a novel gene in the mouse and human major histocompatibility complex class III region, possibly controlling lung tumor susceptibility. Snoek M, et al. Immunogenetics, 2000 Apr. PMID 10803853
    3. Genotype versus phenotype: conflicting results in mapping a lung tumor susceptibility locus to the G7c recombination interval in the mouse MHC class III region. van Kooij M, et al. Immunogenetics, 2001 Oct. PMID 11797099
    4. Molecular analysis of the major MHC recombinational hot spot located within the G7c gene of the murine class III region that is involved in disease susceptibility. Snoek M, et al. J Immunol, 1998 Jan 1. PMID 9551980
    5. The mouse as a model for the effects of MHC genes on human disease. Allcock RJ, et al. Immunol Today, 2000 Jul. PMID 10871872

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    von Willebrand factor A domain-containing protein 7
    Names
    protein G7c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347347.1 → NP_001334276.1  von Willebrand factor A domain-containing protein 7 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC087117
      Consensus CDS
      CCDS84299.1
      UniProtKB/TrEMBL
      B9EJA5
      Related
      ENSMUSP00000133418.2, ENSMUST00000172499.2

    2. NM_138582.1 → NP_613048.1  von Willebrand factor A domain-containing protein 7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_613048.1

      Status: VALIDATED

      Source sequence(s)
      AF134318
      Consensus CDS
      CCDS28672.1
      UniProtKB/Swiss-Prot
      Q9JHA8, Q9Z1Q8
      UniProtKB/TrEMBL
      B2RQ76
      Related
      ENSMUSP00000007245.2, ENSMUST00000007245.8
      Conserved Domains (2) summary
      pfam07217
      Location:164 → 191
      Het-C; Heterokaryon incompatibility protein Het-C
      pfam13519
      Location:319 → 419
      VWA_2; von Willebrand factor type A domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35235388..35245717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317497.3 → XP_017172986.1  von Willebrand factor A domain-containing protein 7 isoform X1

      UniProtKB/Swiss-Prot
      Q9JHA8, Q9Z1Q8
      UniProtKB/TrEMBL
      B2RQ76
      Conserved Domains (2) summary
      pfam07217
      Location:164 → 191
      Het-C; Heterokaryon incompatibility protein Het-C
      pfam13519
      Location:319 → 419
      VWA_2; von Willebrand factor type A domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHA8.1 GenPept UniProtKB/Swiss-Prot:Q9JHA8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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