Brpf1 bromodomain and PHD finger containing, 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Brpf1provided by MGI
Official Full Name: bromodomain and PHD finger containing, 1provided by MGI
Primary source: MGI:MGI:1926033
See related: Ensembl:ENSMUSG00000001632 AllianceGenome:MGI:1926033
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Brpf2; 4833438B11Rik; 4930540D11Rik
Summary: Predicted to enable acetyltransferase activator activity and histone binding activity. Involved in histone H3-K23 acetylation. Acts upstream of or within common myeloid progenitor cell proliferation; regulation of fibroblast proliferation; and tube morphogenesis. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study syndromic intellectual disability. Orthologous to human BRPF1 (bromodomain and PHD finger containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 16.2), CNS E11.5 (RPKM 12.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 52.75 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (113283824..113301823)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (113306863..113324862)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Isoform-specific involvement of Brpf1 in expansion of adult hematopoietic stem and progenitor cells.
Title: Isoform-specific involvement of Brpf1 in expansion of adult hematopoietic stem and progenitor cells.
BRPF1 has a role in development of fetal hematopoietic stem cells
Title: BRPF1 is essential for development of fetal hematopoietic stem cells.
We further demonstrate that Brpf1 loss deregulates neuronal migration, cell cycle progression and transcriptional control, thereby causing abnormal morphogenesis of the hippocampus
Title: The lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors.
a crucial role of Brpf1 in controlling mouse embryo development and regulating cellular and gene expression programs
Title: The chromatin regulator Brpf1 regulates embryo development and cell proliferation.
The 4-dimensional expression atlas of mouse Brpf1 serves as a valuable guide for analyzing its interaction with Moz, Morf, and Hbo1 in vivo, and for investigating whether Brpf1 functions independently of these three enzymatic epigenetic regulators.
Title: Expression atlas of the multivalent epigenetic regulator Brpf1 and its requirement for survival of mouse embryos.
Forebrain-specific inactivation of the Brpf1 gene causes neocortical abnormalities and partial agenesis of the corpus callosum.
Title: Deficiency of the chromatin regulator BRPF1 causes abnormal brain development.
BRPF2 was a novel transcript of BRPF1.
Title: [BRPF2, a novel transcript of BRPF1 and their expression in mice tissues].

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables acetyltransferase activator activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K12 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K5 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K8 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within common myeloid progenitor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of developmental process	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hemopoiesis	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MOZ/MORF histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MOZ/MORF histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peregrin

Names: bromodomain and PHD finger-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282126.1 → NP_001269055.1 peregrin isoform 1

See identical proteins and their annotated locations for NP_001269055.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC155287, AK019522, AK043372, BC046521, BY469507

Consensus CDS

CCDS71809.1

UniProtKB/TrEMBL

B7ZNI3, Q3U109

Related

ENSMUSP00000108744.2, ENSMUST00000113119.8

Conserved Domains (5) summary

cd05839
Location:1116 → 1231

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 728

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
NM_001282127.1 → NP_001269056.1 peregrin isoform 3

See identical proteins and their annotated locations for NP_001269056.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and has multiple differences in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.

Source sequence(s)

AK019522, AK043372, BC046521, BY469507

Consensus CDS

CCDS71810.1

UniProtKB/Swiss-Prot

B2RRD7

UniProtKB/TrEMBL

B7ZNI3

Conserved Domains (5) summary

cd05839
Location:1081 → 1196

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 728

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
NM_001282128.1 → NP_001269057.1 peregrin isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site, and lacks an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.

Source sequence(s)

AC155287, AK019522, AK043372, BC046521, BY469507

Consensus CDS

CCDS85115.1

UniProtKB/TrEMBL

A0A0N4SVG7, B7ZNI3

Related

ENSMUSP00000145093.2, ENSMUST00000204626.3

Conserved Domains (5) summary

cd05839
Location:1087 → 1202

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 734

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
NM_030178.2 → NP_084454.1 peregrin isoform 2

See identical proteins and their annotated locations for NP_084454.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AK019522, AK043372, BC046521, BY469507

Consensus CDS

CCDS39592.1

UniProtKB/TrEMBL

B7ZNI3, Q80XK2

Related

ENSMUSP00000108742.2, ENSMUST00000113117.4

Conserved Domains (5) summary

cd05839
Location:1115 → 1230

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 728

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

113283824..113301823

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506782.5 → XP_006506845.1 peregrin isoform X1

See identical proteins and their annotated locations for XP_006506845.1

UniProtKB/TrEMBL

B7ZNI3

Conserved Domains (5) summary

cd05839
Location:1122 → 1237

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 734

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
XM_006506786.5 → XP_006506849.1 peregrin isoform X5

UniProtKB/TrEMBL

B7ZNI3, E9PXP1

Related

ENSMUSP00000108746.3, ENSMUST00000113121.8

Conserved Domains (5) summary

cd05839
Location:1088 → 1203

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 734

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
XM_017321837.3 → XP_017177326.1 peregrin isoform X9

UniProtKB/TrEMBL

B7ZNI3

Conserved Domains (5) summary

cd05839
Location:1027 → 1142

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 734

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
XM_036152405.1 → XP_036008298.1 peregrin isoform X10

UniProtKB/TrEMBL

B7ZNI3

Conserved Domains (5) summary

cd05839
Location:993 → 1108

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 734

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
XM_006506784.5 → XP_006506847.1 peregrin isoform X2

UniProtKB/TrEMBL

A0A0N4SUT9, B7ZNI3

Related

ENSMUSP00000144820.2, ENSMUST00000203577.2

Conserved Domains (5) summary

cd05839
Location:1121 → 1236

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 734

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
XM_006506783.4 → XP_006506846.1 peregrin isoform X1

See identical proteins and their annotated locations for XP_006506846.1

UniProtKB/TrEMBL

B7ZNI3

Conserved Domains (5) summary

cd05839
Location:1122 → 1237

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 734

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
XM_036152403.1 → XP_036008296.1 peregrin isoform X2

UniProtKB/TrEMBL

A0A0N4SUT9, B7ZNI3

Conserved Domains (5) summary

cd05839
Location:1121 → 1236

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 734

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
XM_036152404.1 → XP_036008297.1 peregrin isoform X6

UniProtKB/TrEMBL

A0A0N4SVG7, B7ZNI3

Conserved Domains (5) summary

cd05839
Location:1087 → 1202

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 734

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
XM_006506785.4 → XP_006506848.1 peregrin isoform X4

See identical proteins and their annotated locations for XP_006506848.1

UniProtKB/TrEMBL

B7ZNI3, Q80XK2

Conserved Domains (5) summary

cd05839
Location:1115 → 1230

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 728

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
XM_006506788.4 → XP_006506851.1 peregrin isoform X8

See identical proteins and their annotated locations for XP_006506851.1

UniProtKB/Swiss-Prot

B2RRD7

UniProtKB/TrEMBL

B7ZNI3

Related

ENSMUSP00000108747.2, ENSMUST00000113122.8

Conserved Domains (5) summary

cd05839
Location:1081 → 1196

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 728

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
XM_006506787.4 → XP_006506850.1 peregrin isoform X7

UniProtKB/TrEMBL

B7ZNI3

Conserved Domains (5) summary

cd05839
Location:1082 → 1197

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 728

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
XM_017321839.2 → XP_017177328.1 peregrin isoform X11

UniProtKB/TrEMBL

A0A0N4SUS4, B7ZNI3

Related

ENSMUSP00000144804.2, ENSMUST00000204198.3

Conserved Domains (5) summary

cd05839
Location:987 → 1102

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 728

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
XM_030255678.2 → XP_030111538.1 peregrin isoform X3

UniProtKB/TrEMBL

B7ZNI3, Q3U109

Conserved Domains (5) summary

cd05839
Location:1116 → 1231

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 728

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
XM_030255679.2 → XP_030111539.1 peregrin isoform X7

UniProtKB/TrEMBL

B7ZNI3

Conserved Domains (5) summary

cd05839
Location:1082 → 1197

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:631 → 728

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:173 → 656

COG5141; PHD zinc finger-containing protein [General function prediction only]

COG5189
Location:20 → 50

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

cd15701
Location:329 → 449

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins