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    Fam98a family with sequence similarity 98, member A [ Mus musculus (house mouse) ]

    Gene ID: 72722, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fam98aprovided by MGI
    Official Full Name
    family with sequence similarity 98, member Aprovided by MGI
    Primary source
    MGI:MGI:1919972
    See related
    Ensembl:ENSMUSG00000002017 AllianceGenome:MGI:1919972
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810405J04Rik
    Summary
    Predicted to enable protein methyltransferase activity. Involved in lysosome localization and positive regulation of ruffle assembly. Predicted to be part of tRNA-splicing ligase complex. Orthologous to human FAM98A (family with sequence similarity 98 member A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 23.3), placenta adult (RPKM 15.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam98a in Genome Data Viewer
    Location:
    17 E2; 17 46.62 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (75844080..75858941, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (75537085..75551946, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene latent transforming growth factor beta binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_43238 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9966 Neighboring gene STARR-seq mESC enhancer starr_43240 Neighboring gene STARR-positive B cell enhancer ABC_E10971 Neighboring gene STARR-seq mESC enhancer starr_43241 Neighboring gene STARR-positive B cell enhancer ABC_E4226 Neighboring gene STARR-seq mESC enhancer starr_43242 Neighboring gene RAS, guanyl releasing protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E8697 Neighboring gene STARR-positive B cell enhancer ABC_E9443 Neighboring gene STARR-positive B cell enhancer ABC_E5628 Neighboring gene STARR-positive B cell enhancer ABC_E7558 Neighboring gene STARR-positive B cell enhancer ABC_E143 Neighboring gene STARR-seq mESC enhancer starr_43246 Neighboring gene STARR-seq mESC enhancer starr_43247 Neighboring gene predicted gene, 53979 Neighboring gene STARR-seq mESC enhancer starr_43248 Neighboring gene lactate dehydrogenase A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis. Fujiwara T, et al. JCI Insight, 2016 Oct 20. PMID 27777970, Free PMC Article
    2. Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. Cassar PA, et al. EMBO Rep, 2015 Oct. PMID 26265008, Free PMC Article
    3. Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system. Zhou J, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Dec. PMID 29055695
    4. Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis. Mugabo Y, et al. J Biol Chem, 2018 May 4. PMID 29530978, Free PMC Article
    5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lysosome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ruffle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of tRNA-splicing ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM98A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357860.1 → NP_001344789.1  protein FAM98A isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT010501
      Conserved Domains (1) summary
      pfam10239
      Location:3 → 132
      DUF2465; Protein of unknown function (DUF2465)

    2. NM_133747.2 → NP_598508.2  protein FAM98A isoform 1

      See identical proteins and their annotated locations for NP_598508.2

      Status: VALIDATED

      Source sequence(s)
      AK167224, BY382397, CJ047600
      Consensus CDS
      CCDS28974.2
      UniProtKB/Swiss-Prot
      Q3TJZ6, Q99KJ2
      Related
      ENSMUSP00000108126.4, ENSMUST00000112507.4
      Conserved Domains (1) summary
      pfam10239
      Location:11 → 327
      DUF2465; Protein of unknown function (DUF2465)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      75844080..75858941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TJZ6.1 GenPept UniProtKB/Swiss-Prot:Q3TJZ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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