Rrm2 ribonucleotide reductase M2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rrm2provided by MGI
Official Full Name: ribonucleotide reductase M2provided by MGI
Primary source: MGI:MGI:98181
See related: Ensembl:ENSMUSG00000020649 AllianceGenome:MGI:98181
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: R2
Summary: Enables ferric iron binding activity and protein homodimerization activity. Contributes to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in deoxyribonucleotide biosynthetic process and protein heterotetramerization. Acts upstream of or within deoxyribonucleotide metabolic process. Part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RRM2 (ribonucleotide reductase regulatory subunit M2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 95.4), liver E14.5 (RPKM 82.1) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.3; 12 8.5 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (24758253..24764145)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (24708254..24714146)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of RRM2 as a key ferroptosis-related gene in sepsis.
Title: Identification of RRM2 as a key ferroptosis-related gene in sepsis.
Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor.
Title: Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor.
Inhibition of RRM2 radiosensitizes glioblastoma and uncovers synthetic lethality in combination with targeting CHK1.
Title: Inhibition of RRM2 radiosensitizes glioblastoma and uncovers synthetic lethality in combination with targeting CHK1.
RRM2 Alleviates Doxorubicin-Induced Cardiotoxicity through the AKT/mTOR Signaling Pathway.
Title: RRM2 Alleviates Doxorubicin-Induced Cardiotoxicity through the AKT/mTOR Signaling Pathway.
This work reveals that binding of RRM1 to RRM2 is essential for mammalian cells and provides the first loss-of-function model of the ribonucleotide reductase complex for genetic studies.
Title: A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development.
mice carrying extra alleles of the RNR regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR activity and reduced chromosomal breakage at fragile sites
Title: Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice.
R2 expression may discriminate cervical cancer phenotype and radiochemotherapy outcome
Title: Ribonucleotide reductase expression in cervical cancer: a radiation therapy oncology group translational science analysis.
analysis of transgenic overexpression of ribonucleotide reductase Rrm1 and Rrm2 improves cardiac performance
Title: Transgenic overexpression of ribonucleotide reductase improves cardiac performance.
Cinobufotalin significantly inhibits the growth of the xenografts of endometrial carcinoma Ishikawa in nude mice by inhibiting RRM2 expression.
Title: [Effect of cinobufotalin on growth of xenograft of endometrial carcinoma cell line ishikawa in nude mouse and its impact on RRM2 expression].
Data suggest that RRM2 may be an important effector of progesterone signaling to induce cell proliferation and decidualization in uterus.
Title: Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236817

RH124586 (e-PCR)
- UniSTS:161408

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ferric iron binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IDA Inferred from Direct Assay more info	PubMed
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IDA Inferred from Direct Assay more info	PubMed
contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in 2'-deoxyribonucleotide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in 2'-deoxyribonucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of blastocyst development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in deoxyribonucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in deoxyribonucleotide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within deoxyribonucleotide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in protein heterotetramerization	IPI Inferred from Physical Interaction more info	PubMed
involved_in ribonucleoside diphosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ribonucleoside diphosphate metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoside-diphosphate reductase complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoside-diphosphate reductase complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of ribonucleoside-diphosphate reductase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribonucleoside-diphosphate reductase subunit M2

Names: ribonucleoside-diphosphate reductase M2 chain; ribonucleotide reductase small chain; ribonucleotide reductase small subunit

NP_033130.1

EC 1.17.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.