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    ASR1 ubiquitin-protein ligase ASR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856208, updated on 17-May-2024

    Summary

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    Gene symbol
    ASR1
    Gene description
    ubiquitin-protein ligase ASR1
    Primary source
    FungiDB:YPR093C
    Locus tag
    YPR093C
    See related
    SGD:S000006297; AllianceGenome:SGD:S000006297; VEuPathDB:YPR093C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin-protein transferase activity. Involved in protein ubiquitination; response to ethanol; and septin ring assembly. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ASR1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (719558..720424, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U2 snRNP complex subunit RDS3 Neighboring gene Arf family guanine nucleotide exchange factor SYT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Response of Saccharomyces cerevisiae to ethanol stress involves actions of protein Asr1p. Ding J, et al. J Microbiol Biotechnol, 2010 Dec. PMID 21193817
    2. Asr1, an alcohol-responsive factor of Saccharomyces cerevisiae, is dispensable for alcoholic fermentation. Izawa S, et al. Appl Microbiol Biotechnol, 2006 Sep. PMID 16391921
    3. Asr1p, a novel yeast ring/PHD finger protein, signals alcohol stress to the nucleus. Betz C, et al. J Biol Chem, 2004 Jul 2. PMID 15117954
    4. The Saccharomyces cerevisiae ubiquitin E3 ligase Asr1p targets calmodulin for ubiquitylation. Fries T, et al. Biochem Biophys Res Commun, 2011 Jul 22. PMID 21726536
    5. A novel role for the alcohol sensitive ring/PHD finger protein Asr1p in regulating cell cycle mediated by septin-dependent assembly in yeast. Zou W, et al. Biochem Biophys Res Commun, 2015 Feb 27. PMID 25646695

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel role for Asr1p in regulating cell cycle mediated by septin-dependent assembly in yeast.Asr1 involved in actin cytoskeleton influence the assembly of septin ring.
      Title: A novel role for the alcohol sensitive ring/PHD finger protein Asr1p in regulating cell cycle mediated by septin-dependent assembly in yeast.
    2. a role of the Asr1p E3 ligase activity in coping with stress is proposed.
      Title: The Saccharomyces cerevisiae ubiquitin E3 ligase Asr1p targets calmodulin for ubiquitylation.
    3. Thus, when taken together, the present results suggest that Asr1 is involved in the response to ethanol stress in the yeast S. cerevisiae.
      Title: Response of Saccharomyces cerevisiae to ethanol stress involves actions of protein Asr1p.
    4. Asr1 is a RING finger ubiquitin-ligase that binds directly to RNA polymerase II via the carboxyl-terminal domain of the largest subunit of the enzyme.
      Title: Modulation of RNA polymerase II subunit composition by ubiquitylation.
    5. it was concluded that Asr1 is not required and nor important for tolerance to alcohol stress
      Title: Asr1, an alcohol-responsive factor of Saccharomyces cerevisiae, is dispensable for alcoholic fermentation.
    6. Deletion of ASR1 leads to sensitivity in growth on medium containing alcohol or detergent, consistent with a function of Asr1p in alcohol-related signaling.
      Title: Asr1p, a novel yeast ring/PHD finger protein, signals alcohol stress to the nucleus.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septin ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-protein ligase ASR1
    NP_015418.2
    • Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      719558..720424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184190.1 → NP_015418.2  TPA: ubiquitin-protein ligase ASR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015418.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W492, Q06834
      UniProtKB/TrEMBL
      A0A8H4BW82, B3LK59, C8ZJB6
      Conserved Domains (2) summary
      smart00249
      Location:121 → 167
      PHD; PHD zinc finger
      cd16448
      Location:4 → 48
      RING-H2; H2 subclass of RING (RING-H2) finger and its variants
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06834.2

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