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    Homez homeodomain leucine zipper-encoding gene [ Mus musculus (house mouse) ]

    Gene ID: 239099, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Homezprovided by MGI
    Official Full Name
    homeodomain leucine zipper-encoding geneprovided by MGI
    Primary source
    MGI:MGI:2678023
    See related
    Ensembl:ENSMUSG00000057156 AllianceGenome:MGI:2678023
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1443
    Summary
    Enables DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including enteric nervous system; future brain; genitourinary system; liver; and sensory organ. Orthologous to human HOMEZ (homeobox and leucine zipper encoding). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.4), ovary adult (RPKM 1.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Homez in Genome Data Viewer
    Location:
    14 C3; 14 27.96 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55090193..55109285, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54852736..54871728, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 Neighboring gene ring finger protein 212B Neighboring gene STARR-seq mESC enhancer starr_36747 Neighboring gene predicted gene, 17772 Neighboring gene STARR-positive B cell enhancer ABC_E4110 Neighboring gene protein phosphatase 1, regulatory subunit 3E Neighboring gene BCL2-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. Bayarsaihan D, et al. Proc Natl Acad Sci U S A, 2003 Sep 2. PMID 12925734, Free PMC Article
    2. The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation. Carmona-Mora P, et al. Hum Genet, 2015 Oct. PMID 26275350
    3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    4. Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Memic F, et al. Gastroenterology, 2018 Feb. PMID 29031500, Free PMC Article
    5. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox and leucine zipper protein Homez
    Names
    homeodomain leucine zipper-containing factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177705.2 → NP_001171176.1  homeobox and leucine zipper protein Homez isoform 1

      See identical proteins and their annotated locations for NP_001171176.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC116591
      Consensus CDS
      CCDS27102.1
      UniProtKB/Swiss-Prot
      Q504Z8, Q80W88
      UniProtKB/TrEMBL
      A0A0R4J108
      Related
      ENSMUSP00000117828.2, ENSMUST00000142283.4
      Conserved Domains (3) summary
      COG5576
      Location:274 → 417
      COG5576; Homeodomain-containing transcription factor [Transcription]
      cd00086
      Location:328 → 385
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:430 → 476
      Homez; Homeodomain leucine-zipper encoding, Homez

    2. NM_001425853.1 → NP_001412782.1  homeobox and leucine zipper protein Homez isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116591

    3. NM_001425855.1 → NP_001412784.1  homeobox and leucine zipper protein Homez isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116591

    4. NM_001425856.1 → NP_001412785.1  homeobox and leucine zipper protein Homez isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116591

    5. NM_183174.3 → NP_898997.2  homeobox and leucine zipper protein Homez isoform 1

      See identical proteins and their annotated locations for NP_898997.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC116591, BC094669
      Consensus CDS
      CCDS27102.1
      UniProtKB/Swiss-Prot
      Q504Z8, Q80W88
      UniProtKB/TrEMBL
      A0A0R4J108
      Related
      ENSMUSP00000079929.6, ENSMUST00000081162.6
      Conserved Domains (3) summary
      COG5576
      Location:274 → 417
      COG5576; Homeodomain-containing transcription factor [Transcription]
      cd00086
      Location:328 → 385
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:430 → 476
      Homez; Homeodomain leucine-zipper encoding, Homez

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55090193..55109285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518978.5 → XP_006519041.1  homeobox and leucine zipper protein Homez isoform X3

      UniProtKB/Swiss-Prot
      Q504Z8, Q80W88
      Conserved Domains (3) summary
      COG5576
      Location:313 → 456
      COG5576; Homeodomain-containing transcription factor [Transcription]
      cd00086
      Location:367 → 424
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:469 → 515
      Homez; Homeodomain leucine-zipper encoding, Homez
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80W88.2 GenPept UniProtKB/Swiss-Prot:Q80W88

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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