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    Them7 thioesterase superfamily member 7 [ Mus musculus (house mouse) ]

    Gene ID: 74088, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Them7provided by MGI
    Official Full Name
    thioesterase superfamily member 7provided by MGI
    Primary source
    MGI:MGI:1921338
    See related
    Ensembl:ENSMUSG00000055312 AllianceGenome:MGI:1921338
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610012H03Rik
    Summary
    Predicted to enable acyl-CoA hydrolase activity. Located in mitochondrion. Orthologous to human THEM7P (thioesterase superfamily member 7, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 49.1) and liver adult (RPKM 8.3) See more
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    Genomic context

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    See Them7 in Genome Data Viewer
    Location:
    2 E3; 2 55.09 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (105054687..105210205)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (105224342..105379860)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05302 Neighboring gene WT1 transcription factor, opposite strand Neighboring gene Wt1 promoter region Neighboring gene WT1 transcription factor Neighboring gene STARR-seq mESC enhancer starr_05304 Neighboring gene STARR-seq mESC enhancer starr_05306 Neighboring gene STARR-seq mESC enhancer starr_05307 Neighboring gene reticulocalbin 1 Neighboring gene predicted gene, 39900

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein LOC74088

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159638.1 → NP_001153110.1  uncharacterized protein LOC74088 isoform 2

      See identical proteins and their annotated locations for NP_001153110.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the alternate exon containing the translation start site compared to variant 1. This transcript uses a downstream in-frame translation start site, and the encoded isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK002603, AK143809, CB952425
      UniProtKB/TrEMBL
      Q6PER5
      Conserved Domains (1) summary
      cd00586
      Location:38 → 175
      4HBT; 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. ...

    2. NM_028747.2 → NP_083023.1  uncharacterized protein LOC74088 isoform 1

      See identical proteins and their annotated locations for NP_083023.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK002603, AK143809, CB952425
      Consensus CDS
      CCDS38191.1
      UniProtKB/TrEMBL
      Q6PER5, Q9DCP4
      Related
      ENSMUSP00000063340.3, ENSMUST00000068813.3
      Conserved Domains (1) summary
      cd00586
      Location:62 → 199
      4HBT; 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      105054687..105210205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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