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    UBP2 ubiquitin-specific protease 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839397, updated on 15-Oct-2023

    Summary

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    Gene symbol
    UBP2
    Gene description
    ubiquitin-specific protease 2
    Primary source
    Araport:AT1G04860
    Locus tag
    AT1G04860
    See related
    TAIR:AT1G04860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATUBP2; F13M7.15; F13M7_15; ubiquitin-specific protease 2; UBIQUITIN-SPECIFIC PROTEASE 2
    Summary
    Encodes a ubiquitin-specific protease.
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    Genomic context

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    See UBP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (1369036..1373103, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ubiquitin-associated (UBA)/TS-N domain-containing protein Neighboring gene protein arginine methyltransferase 10 Neighboring gene HMG (high mobility group) box protein with ARID/BRIGHT DNA-binding domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin/26S proteasome pathway, the complex last chapter in the life of many plant proteins. Vierstra RD. Trends Plant Sci, 2003 Mar. PMID 12663224
    2. The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine. Yan N, et al. Plant Physiol, 2000 Dec. PMID 11115897, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_100364.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of proteasome complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin-specific protease 2
    NP_563719.1
    • ubiquitin-specific protease 2 (UBP2); FUNCTIONS IN: ubiquitin-specific protease activity; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome complex, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, UBP-type (InterPro:IPR001607), Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site (InterPro:IPR018200), Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (InterPro:IPR001394); BEST Arabidopsis thaliana protein match is: ubiquitin-specific protease 1 (TAIR:AT2G32780.1); Has 10400 Blast hits to 6714 proteins in 274 species: Archae - 0; Bacteria - 50; Metazoa - 5279; Fungi - 1927; Plants - 1459; Viruses - 5; Other Eukaryotes - 1680 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1369036..1373103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100364.4 → NP_563719.1  ubiquitin-specific protease 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563719.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8W4N3, Q9MAT4
      UniProtKB/TrEMBL
      A0A178WGQ0, A0A654E7V8
      Conserved Domains (3) summary
      COG5560
      Location:232 → 956
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cl02553
      Location:703 → 955
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam02148
      Location:105 → 161
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W4N3.2

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