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    Parp4 poly (ADP-ribose) polymerase family, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 328417, updated on 9-May-2024

    Summary

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    Official Symbol
    Parp4provided by MGI
    Official Full Name
    poly (ADP-ribose) polymerase family, member 4provided by MGI
    Primary source
    MGI:MGI:2685589
    See related
    Ensembl:ENSMUSG00000054509 AllianceGenome:MGI:2685589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PH5P; p193; ARTD4; Gm743; PARPL; VPARP; PARP-4; VAULT3; Adprtl1; C030027K23Rik; E230037B21Rik
    Summary
    Predicted to enable NAD+ ADP-ribosyltransferase activity; enzyme binding activity; and protein ADP-ribosylase activity. Predicted to be involved in several processes, including inflammatory response; protein mono-ADP-ribosylation; and regulation of telomerase activity. Predicted to act upstream of or within protein ADP-ribosylation. Predicted to be located in cytosol and spindle microtubule. Orthologous to human PARP4 (poly(ADP-ribose) polymerase family member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.9), placenta adult (RPKM 4.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Parp4 in Genome Data Viewer
    Location:
    14 C3; 14 28.31 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56812982..56897256)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56575619..56659798)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 17 Neighboring gene predicted gene, 50496 Neighboring gene predicted gene, 24392 Neighboring gene STARR-seq mESC enhancer starr_36796 Neighboring gene centromere protein J Neighboring gene STARR-positive B cell enhancer ABC_E10828 Neighboring gene STARR-positive B cell enhancer ABC_E5442 Neighboring gene predicted gene 16573 Neighboring gene STARR-positive B cell enhancer ABC_E755 Neighboring gene basic transcription factor 3, pseudogene 18 Neighboring gene M-phase phosphoprotein 8 Neighboring gene predicted gene, 16973

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis. Raval-Fernandes S, et al. Cancer Res, 2005 Oct 1. PMID 16204055
    2. Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. Liu Y, et al. Mol Cell Biol, 2004 Jun. PMID 15169895, Free PMC Article
    3. The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons. Vezzali R, et al. Oncotarget, 2016 Jun 21. PMID 27224923, Free PMC Article
    4. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    5. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+-protein ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within telomere maintenance via telomerase IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein mono-ADP-ribosyltransferase PARP4
    Names
    ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1
    ADP-ribosyltransferase diphtheria toxin-like 4
    mVparp
    poly [ADP-ribose] polymerase 4
    vault poly(ADP-ribose) polymerase
    NP_001139450.2
    XP_036014573.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145978.2 → NP_001139450.2  protein mono-ADP-ribosyltransferase PARP4

      Status: VALIDATED

      Source sequence(s)
      AC154731, AK053992, AK164513, AK172907
      Consensus CDS
      CCDS49503.1
      UniProtKB/Swiss-Prot
      E9PYK3, Q6A0B1, Q80UW6, Q8BW82, Q8R3A5
      Related
      ENSMUSP00000124258.2, ENSMUST00000161553.2
      Conserved Domains (7) summary
      smart00292
      Location:4 → 81
      BRCT; breast cancer carboxy-terminal domain
      smart00327
      Location:870 → 1026
      VWA; von Willebrand factor (vWF) type A domain
      cd01437
      Location:244 → 557
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      TIGR03788
      Location:629 → 1174
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam00644
      Location:371 → 559
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam06346
      Location:1394 → 1608
      Drf_FH1; Formin Homology Region 1
      pfam08487
      Location:616 → 724
      VIT; Vault protein inter-alpha-trypsin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      56812982..56897256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158680.1 → XP_036014573.1  protein mono-ADP-ribosyltransferase PARP4 isoform X1

      Conserved Domains (3) summary
      smart00327
      Location:167 → 323
      VWA; von Willebrand factor (vWF) type A domain
      pfam06346
      Location:746 → 915
      Drf_FH1; Formin Homology Region 1
      cl02699
      Location:1 → 23
      VIT; Vault protein inter-alpha-trypsin domain

    RNA

    1. XR_383191.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9PYK3.1 GenPept UniProtKB/Swiss-Prot:E9PYK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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