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    Ppp1r18 protein phosphatase 1, regulatory subunit 18 [ Mus musculus (house mouse) ]

    Gene ID: 76448, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ppp1r18provided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 18provided by MGI
    Primary source
    MGI:MGI:1923698
    See related
    Ensembl:ENSMUSG00000034595 AllianceGenome:MGI:1923698
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310014H01Rik
    Summary
    Predicted to enable actin binding activity and phosphatase binding activity. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in nervous system. Orthologous to human PPP1R18 (protein phosphatase 1 regulatory subunit 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen adult (RPKM 30.8), thymus adult (RPKM 21.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp1r18 in Genome Data Viewer
    Location:
    17 B1; 17 18.72 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36176483..36186488)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35865593..35875596)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42479 Neighboring gene mediator of DNA damage checkpoint 1 Neighboring gene nurim (nuclear envelope membrane protein) Neighboring gene STARR-seq mESC enhancer starr_42480 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:36016615-36016802 Neighboring gene DEAH-box helicase 16 Neighboring gene RIKEN cDNA 2310061I04 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs. Lee HS, et al. J Exp Med, 2022 Aug 1. PMID 35766979, Free PMC Article
    2. The Actin-Binding Protein PPP1r18 Regulates Maturation, Actin Organization, and Bone Resorption Activity of Osteoclasts. Matsubara T, et al. Mol Cell Biol, 2018 Feb 15. PMID 29158294, Free PMC Article
    3. Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry. Del Mar Masdeu M, et al. Oncotarget, 2017 Nov 24. PMID 29254152, Free PMC Article
    4. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article
    5. Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Chiang DY, et al. Circulation, 2018 Oct 9. PMID 29669786, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs.
      Title: Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phostensin
    Names
    protein phosphatase 1 F-actin cytoskeleton-targeting subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146710.1 → NP_001140182.1  phostensin isoform 1

      See identical proteins and their annotated locations for NP_001140182.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK009340, AK149943
      Consensus CDS
      CCDS50094.1
      UniProtKB/Swiss-Prot
      B8JJ63, B8JJ64, Q3UDS6, Q8BQ30, Q8CEY9, Q8R3D8
      UniProtKB/TrEMBL
      B2RWV7, B7ZND7
      Related
      ENSMUSP00000120343.2, ENSMUST00000122899.8
      Conserved Domains (2) summary
      pfam13914
      Location:425 → 540
      Phostensin; Phostensin PP1-binding and SH3-binding region
      pfam13916
      Location:28 → 117
      Phostensin_N; PP1-regulatory protein, Phostensin N-terminal

    2. NM_001146711.1 → NP_001140183.1  phostensin isoform 1

      See identical proteins and their annotated locations for NP_001140183.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      CR974451
      Consensus CDS
      CCDS50094.1
      UniProtKB/Swiss-Prot
      B8JJ63, B8JJ64, Q3UDS6, Q8BQ30, Q8CEY9, Q8R3D8
      UniProtKB/TrEMBL
      B2RWV7, B7ZND7
      Related
      ENSMUSP00000116100.2, ENSMUST00000144382.8
      Conserved Domains (2) summary
      pfam13914
      Location:425 → 540
      Phostensin; Phostensin PP1-binding and SH3-binding region
      pfam13916
      Location:28 → 117
      Phostensin_N; PP1-regulatory protein, Phostensin N-terminal

    3. NM_001378889.1 → NP_001365818.1  phostensin isoform 2

      Status: VALIDATED

      Source sequence(s)
      CR974451
      UniProtKB/TrEMBL
      B2RWV7, B7ZND7
      Conserved Domains (2) summary
      pfam13914
      Location:468 → 583
      Phostensin; Phostensin PP1-binding and SH3-binding region
      pfam13916
      Location:71 → 160
      Phostensin_N; PP1-regulatory protein, Phostensin N-terminal

    4. NM_175242.1 → NP_780451.1  phostensin isoform 1

      See identical proteins and their annotated locations for NP_780451.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK051656, BY198945, CR974451
      Consensus CDS
      CCDS50094.1
      UniProtKB/Swiss-Prot
      B8JJ63, B8JJ64, Q3UDS6, Q8BQ30, Q8CEY9, Q8R3D8
      UniProtKB/TrEMBL
      B2RWV7, B7ZND7
      Related
      ENSMUSP00000141094.2, ENSMUST00000187690.7
      Conserved Domains (2) summary
      pfam13914
      Location:425 → 540
      Phostensin; Phostensin PP1-binding and SH3-binding region
      pfam13916
      Location:28 → 117
      Phostensin_N; PP1-regulatory protein, Phostensin N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      36176483..36186488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525092.5 → XP_006525155.2  phostensin isoform X1

      UniProtKB/TrEMBL
      B2RWV7, B7ZND7
      Related
      ENSMUSP00000115753.2, ENSMUST00000127442.8
      Conserved Domains (2) summary
      pfam13914
      Location:425 → 540
      Phostensin; Phostensin PP1-binding and SH3-binding region
      pfam13916
      Location:28 → 117
      Phostensin_N; PP1-regulatory protein, Phostensin N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQ30.1 GenPept UniProtKB/Swiss-Prot:Q8BQ30

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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