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    Psmg3 proteasome (prosome, macropain) assembly chaperone 3 [ Mus musculus (house mouse) ]

    Gene ID: 66506, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Psmg3provided by MGI
    Official Full Name
    proteasome (prosome, macropain) assembly chaperone 3provided by MGI
    Primary source
    MGI:MGI:1913756
    See related
    Ensembl:ENSMUSG00000029551 AllianceGenome:MGI:1913756
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810042K04Rik; 4930403H09Rik
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in chaperone-mediated protein complex assembly. Part of protein-containing complex. Orthologous to human PSMG3 (proteasome assembly chaperone 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 18.5), large intestine adult (RPKM 17.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Psmg3 in Genome Data Viewer
    Location:
    5 G2; 5 78.81 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139809368..139812649, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139823613..139826894, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4803 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140268130-140268313 Neighboring gene STARR-seq mESC enhancer starr_14698 Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) Neighboring gene transmembrane protein 184a Neighboring gene predicted gene, 38727 Neighboring gene leucine rich repeat and fibronectin type III, extracellular 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals. Le Tallec B, et al. Mol Cell, 2007 Aug 17. PMID 17707236
    2. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proteasome assembly chaperone 3
    Names
    PAC-3
    mPAC3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356963.1 → NP_001343892.1  proteasome assembly chaperone 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BE848654, CB203764
      Consensus CDS
      CCDS19815.1
      UniProtKB/Swiss-Prot
      Q9CZH3
      Related
      ENSMUSP00000138161.2, ENSMUST00000182602.2
      Conserved Domains (1) summary
      pfam10178
      Location:34 → 117
      PAC3; Proteasome assembly chaperone 3

    2. NM_025604.4 → NP_079880.1  proteasome assembly chaperone 3

      See identical proteins and their annotated locations for NP_079880.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK012616, BE848654
      Consensus CDS
      CCDS19815.1
      UniProtKB/Swiss-Prot
      Q9CZH3
      Related
      ENSMUSP00000031531.7, ENSMUST00000031531.14
      Conserved Domains (1) summary
      pfam10178
      Location:34 → 117
      PAC3; Proteasome assembly chaperone 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      139809368..139812649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZH3.1 GenPept UniProtKB/Swiss-Prot:Q9CZH3

    Gene LinkOut

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