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    Inava innate immunity activator [ Mus musculus (house mouse) ]

    Gene ID: 67313, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Inavaprovided by MGI
    Official Full Name
    innate immunity activatorprovided by MGI
    Primary source
    MGI:MGI:1921579
    See related
    Ensembl:ENSMUSG00000041605 AllianceGenome:MGI:1921579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D1Mgi54; 1700034M08Rik; 4933426C09Rik; 5730559C18Rik
    Summary
    Involved in adherens junction maintenance; intestinal epithelial structure maintenance; and positive regulation of protein ubiquitination. Predicted to be located in cytoplasm and nucleus. Is expressed in alimentary system; metanephros; olfactory epithelium; and respiratory system. Human ortholog(s) of this gene implicated in inflammatory bowel disease 29. Orthologous to human INAVA (innate immunity activator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 37.5), stomach adult (RPKM 18.3) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Inava in Genome Data Viewer
    Location:
    1 E4; 1 59.61 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (136141259..136162045, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (136213522..136234293, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2562 Neighboring gene STARR-positive B cell enhancer ABC_E1562 Neighboring gene STARR-positive B cell enhancer mm9_chr1:138036481-138036781 Neighboring gene kinesin family member 21B Neighboring gene maestro heat-like repeat family member 3 Neighboring gene STARR-seq mESC enhancer starr_02404 Neighboring gene predicted gene 3878 Neighboring gene G protein-coupled receptor 25 Neighboring gene calmodulin regulated spectrin-associated protein family, member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Mohanan V, et al. Science, 2018 Mar 9. PMID 29420262, Free PMC Article
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10901

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adherens junction maintenance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adherens junction maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intestinal epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to muramyl dipeptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to peptidoglycan ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    innate immunity activator protein
    Names
    uncharacterized protein C1orf106 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405152.1 → NP_001392081.1  innate immunity activator protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124550

    2. NM_001405153.1 → NP_001392082.1  innate immunity activator protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124550

    3. NM_001405154.1 → NP_001392083.1  innate immunity activator protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124550

    4. NM_028872.4 → NP_083148.4  innate immunity activator protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124550
      Consensus CDS
      CCDS15325.2
      UniProtKB/Swiss-Prot
      Q7TN12, Q7TN27, Q8BGK3
      Related
      ENSMUSP00000113785.3, ENSMUST00000120339.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      136141259..136162045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153122.1 → XP_036009015.1  innate immunity activator protein isoform X2

      UniProtKB/TrEMBL
      G3X9Z8
      Conserved Domains (1) summary
      pfam11819
      Location:2 → 130
      DUF3338; Domain of unknown function (DUF3338)

    2. XM_036153121.1 → XP_036009014.1  innate immunity activator protein isoform X2

      UniProtKB/TrEMBL
      G3X9Z8
      Conserved Domains (1) summary
      pfam11819
      Location:2 → 130
      DUF3338; Domain of unknown function (DUF3338)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TN12.1 GenPept UniProtKB/Swiss-Prot:Q7TN12

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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