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    Myo3b myosin IIIB [ Mus musculus (house mouse) ]

    Gene ID: 329421, updated on 12-May-2024

    Summary

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    Official Symbol
    Myo3bprovided by MGI
    Official Full Name
    myosin IIIBprovided by MGI
    Primary source
    MGI:MGI:2448580
    See related
    Ensembl:ENSMUSG00000042064 AllianceGenome:MGI:2448580
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A430065P19Rik
    Summary
    Enables microfilament motor activity and protein serine/threonine kinase activity. Involved in auditory receptor cell stereocilium organization; cochlea morphogenesis; and sensory perception of sound. Acts upstream of or within positive regulation of filopodium assembly; protein phosphorylation; and regulation of actin filament length. Located in filopodium tip; photoreceptor inner segment; and photoreceptor outer segment. Is active in stereocilium tip. Is expressed in several structures, including genitourinary system; nervous system; and submandibular gland. Orthologous to human MYO3B (myosin IIIB). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in genital fat pad adult (RPKM 8.0), kidney adult (RPKM 0.5) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Myo3b in Genome Data Viewer
    Location:
    2 C2; 2 41.05 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69869464..70259542)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (70039126..70429195)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11134 Neighboring gene STARR-seq mESC enhancer starr_04746 Neighboring gene STARR-positive B cell enhancer ABC_E508 Neighboring gene methyltransferase 5, N6-adenosine Neighboring gene STARR-seq mESC enhancer starr_04748 Neighboring gene small RNA binding exonuclease protection factor La Neighboring gene STARR-positive B cell enhancer ABC_E9515 Neighboring gene STARR-seq mESC enhancer starr_04749 Neighboring gene ubiquitin protein ligase E3 component n-recognin 3 Neighboring gene STARR-seq mESC enhancer starr_04750 Neighboring gene STARR-positive B cell enhancer ABC_E4463 Neighboring gene STARR-seq mESC enhancer starr_04751 Neighboring gene STARR-seq mESC enhancer starr_04752 Neighboring gene STARR-seq mESC enhancer starr_04756 Neighboring gene STARR-seq mESC enhancer starr_04757 Neighboring gene STARR-seq mESC enhancer starr_04758 Neighboring gene STARR-seq mESC enhancer starr_04760 Neighboring gene ribosomal protein L9, pseudogene 7 Neighboring gene trans-acting transcription factor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse class III myosins: kinase activity and phosphorylation sites. Dalal JS, et al. J Neurochem, 2011 Nov. PMID 21895655, Free PMC Article
    2. Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like. Ebrahim S, et al. Nat Commun, 2016 Mar 1. PMID 26926603, Free PMC Article
    3. Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions. Merritt RC, et al. Curr Biol, 2012 Feb 21. PMID 22264607, Free PMC Article
    4. Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments. Katti C, et al. Exp Eye Res, 2009 Aug. PMID 19332056, Free PMC Article
    5. Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. Lelli A, et al. J Cell Biol, 2016 Jan 18. PMID 26754646, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in auditory receptor cell stereocilium organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in auditory receptor cell stereocilium organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cochlea morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of filopodium assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of actin filament length IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin filament length IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin filament length IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in filopodium tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in filopodium tip IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in photoreceptor inner segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in stereocilium tip EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in stereocilium tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stereocilium tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myosin-IIIb
    Names
    myosin IIIB1
    myosin IIIB2
    NP_796350.2
    XP_006499808.1
    XP_006499813.1
    XP_017174526.1
    XP_017174527.1
    XP_017174528.1
    XP_017174529.1
    XP_017174530.1
    XP_017174531.1
    XP_017174532.1
    XP_017174534.1
    XP_030107661.1
    XP_036018214.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177376.5 → NP_796350.2  myosin-IIIb

      See identical proteins and their annotated locations for NP_796350.2

      Status: VALIDATED

      Source sequence(s)
      AL845263, AL929164, AL929249
      Consensus CDS
      CCDS38139.1
      UniProtKB/TrEMBL
      F8VQ79
      Related
      ENSMUSP00000055362.4, ENSMUST00000060208.11
      Conserved Domains (4) summary
      smart00220
      Location:43 → 309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00242
      Location:362 → 1069
      MYSc; Myosin. Large ATPases
      cd06639
      Location:20 → 310
      STKc_myosinIIIB_N; N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin
      cd01379
      Location:373 → 1062
      MYSc_Myo3; class III myosin, motor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      69869464..70259542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319039.1 → XP_017174528.1  myosin-IIIb isoform X3

      UniProtKB/Swiss-Prot
      A2AR19, Q1EG26, Q1EG27
      Related
      ENSMUSP00000107862.2, ENSMUST00000112243.8
      Conserved Domains (2) summary
      cd01379
      Location:345 → 1034
      MYSc_Myo3; class III myosin, motor domain
      cl21453
      Location:1 → 282
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006499745.5 → XP_006499808.1  myosin-IIIb isoform X1

      Conserved Domains (2) summary
      cd01379
      Location:345 → 1051
      MYSc_Myo3; class III myosin, motor domain
      cl21453
      Location:1 → 282
      PKc_like; Protein Kinases, catalytic domain

    3. XM_017319038.3 → XP_017174527.1  myosin-IIIb isoform X2

      Conserved Domains (2) summary
      cd01379
      Location:345 → 1037
      MYSc_Myo3; class III myosin, motor domain
      cl21453
      Location:1 → 282
      PKc_like; Protein Kinases, catalytic domain

    4. XM_017319040.3 → XP_017174529.1  myosin-IIIb isoform X4

      Conserved Domains (2) summary
      cd01379
      Location:323 → 1029
      MYSc_Myo3; class III myosin, motor domain
      cl21453
      Location:1 → 260
      PKc_like; Protein Kinases, catalytic domain

    5. XM_006499750.5 → XP_006499813.1  myosin-IIIb isoform X5

      Conserved Domains (2) summary
      cd01379
      Location:310 → 1016
      MYSc_Myo3; class III myosin, motor domain
      cl21453
      Location:1 → 247
      PKc_like; Protein Kinases, catalytic domain

    6. XM_017319042.3 → XP_017174531.1  myosin-IIIb isoform X7

      Conserved Domains (2) summary
      cd01379
      Location:345 → 1051
      MYSc_Myo3; class III myosin, motor domain
      cl21453
      Location:1 → 282
      PKc_like; Protein Kinases, catalytic domain

    7. XM_017319043.3 → XP_017174532.1  myosin-IIIb isoform X8

      Conserved Domains (2) summary
      cd01379
      Location:345 → 1051
      MYSc_Myo3; class III myosin, motor domain
      cl21453
      Location:1 → 282
      PKc_like; Protein Kinases, catalytic domain

    8. XM_017319041.2 → XP_017174530.1  myosin-IIIb isoform X6

      Conserved Domains (2) summary
      cd01379
      Location:345 → 1051
      MYSc_Myo3; class III myosin, motor domain
      cl21453
      Location:1 → 282
      PKc_like; Protein Kinases, catalytic domain

    9. XM_017319045.1 → XP_017174534.1  myosin-IIIb isoform X10

      Conserved Domains (2) summary
      cl22853
      Location:345 → 862
      Motor_domain; Myosin and Kinesin motor domain
      cl21453
      Location:1 → 282
      PKc_like; Protein Kinases, catalytic domain

    10. XM_030251801.1 → XP_030107661.1  myosin-IIIb isoform X11

      Conserved Domains (1) summary
      cl21453
      Location:1 → 238
      PKc_like; Protein Kinases, catalytic domain

    11. XM_017319037.3 → XP_017174526.1  myosin-IIIb isoform X1

      Conserved Domains (2) summary
      cd01379
      Location:345 → 1051
      MYSc_Myo3; class III myosin, motor domain
      cl21453
      Location:1 → 282
      PKc_like; Protein Kinases, catalytic domain

    12. XM_036162321.1 → XP_036018214.1  myosin-IIIb isoform X9

      Conserved Domains (4) summary
      smart00015
      Location:886 → 908
      IQ; Calmodulin-binding motif
      cd01379
      Location:140 → 846
      MYSc_Myo3; class III myosin, motor domain
      cd22307
      Location:878 → 926
      Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif
      cl21453
      Location:34 → 77
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_004940647.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001042509.1: Suppressed sequence

      Description
      NM_001042509.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1EG27.2 GenPept UniProtKB/Swiss-Prot:Q1EG27

    Gene LinkOut

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